Observational studyJournal of ultrasound2025
Lung ultrasound and coagulation activation in COVID-19 pneumonia.
Observational study in Journal of ultrasound, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Clinical utility of lung ultrasound in differentiating and monitoring complicated pediatric pneumonia: a prospective diagnostic accuracy study.Italian journal of pediatrics · 2026Article
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Authors and funding
8 authors.
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Abstract
purposeTo evaluate the correlation between the degree of pulmonary compromise, as assessed by lung ultrasound, and the activation of the coagulation cascade in patients hospitalized with COVID-19 pneumonia.
methodsA prospective observational study was conducted on 47 adult patients with confirmed COVID-19 pneumonia. Each patient underwent a systematic 12-zone LUS exam to calculate a total Lung Ultrasound Score (LUS score). Arterial blood gas analysis was performed to calculate the arterial partial pressure of oxygen to fraction of inspired oxygen (P/F) ratio and the alveolar-arterial (A-a) oxygen gradient. Laboratory tests included serum D-dimer and C-reactive protein (CRP).
resultsThe LUS score correlated positively and significantly with D-dimer values (p = 0.019; ρ = 0.342), CRP (p < 0.001; ρ = 0.647), and the A-a gradient (p < 0.001; ρ = 0.640). It also displayed a significant negative correlation with the P/F ratio (p < 0.001; ρ = -0.614).
conclusionThe degree of lung injury in COVID-19 pneumonia, as evaluated by LUS, correlates directly with elevated D-dimer levels, signifying increased coagulation activation. Lung ultrasound, as a bedside and noninvasive tool, could serve as a surrogate marker not only for pulmonary involvement but also for identifying patients at higher risk of thrombotic complications.
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