Evidence map›Paper›PMID 40731177›Full record

Observational studyPediatric cardiology2026

Evaluation of Biventricular Diastolic Function in Preterm Infants in the First Week of Postnatal Life.

Ivonne Sierra-Strum, Rutuja Kibe, Piyawat Arichai, Hemananda Muniraman, Ebrahimi Mahmood, Rowena Cayabyab, Yogen Singh, Rangasamy Ramanathan

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ivonne Sierra-StrumDepartment of Pediatrics, Division of Neonatal Medicine, Keck School of Medicine, Los Angeles General Medical Center, University of Southern California, 2051 Marengo Street, IRD Building, Room 820, Los Angeles, CA, 90033, USA. ivonnesierra7@gmail.com.ORCID http://orcid.org/0000-0001-5808-6781
Rutuja KibeDepartment of Pediatrics, Division of Neonatology, Kapiolani Medical Center for Women and Children, Honolulu, HI, USA.
Piyawat ArichaiDepartment of Pediatrics, Division of Neonatal Medicine, Keck School of Medicine, Los Angeles General Medical Center, University of Southern California, 2051 Marengo Street, IRD Building, Room 820, Los Angeles, CA, 90033, USA.ORCID http://orcid.org/0000-0001-9520-2956
Hemananda MuniramanDepartment of Pediatrics, Division of Neonatal Medicine, Keck School of Medicine, Los Angeles General Medical Center, University of Southern California, 2051 Marengo Street, IRD Building, Room 820, Los Angeles, CA, 90033, USA.ORCID http://orcid.org/0000-0003-0254-2607
Ebrahimi MahmoodDepartment of Pediatrics, Division of Neonatology, Cedars Sinai Guerin Children's, Cedars Sinai Medical Center, Los Angeles, CA, USA.
Rowena CayabyabDepartment of Pediatrics, Division of Neonatal Medicine, Keck School of Medicine, Los Angeles General Medical Center, University of Southern California, 2051 Marengo Street, IRD Building, Room 820, Los Angeles, CA, 90033, USA.
Yogen SinghDepartment of Pediatrics, Division of Neonatology, UC Davis Children's Hospital, UC Davis Health, Sacramento, CA, USA.ORCID http://orcid.org/0000-0002-5207-9019
Rangasamy RamanathanDepartment of Pediatrics, Division of Neonatology, Cedars Sinai Guerin Children's, Cedars Sinai Medical Center, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-7358-601X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diastolic dysfunction contributes significantly to respiratory instability in preterm infants but remains under-characterized during early postnatal transition. We aimed to evaluate the evolution of biventricular diastolic function during the first week of life in very low birth weight (VLBW) preterm infants. In this prospective observational study, 20 preterm infants (< 32 weeks gestation or < 1500 g) underwent serial echocardiograms at 24, 48, 72 h, and day 7. TDI mitral/tricuspid inflow velocities, left atrial (LA) volume, cardiac output, and shunt characteristics were measured. Hemodynamically significant PDA (hsPDA) was defined by standard echocardiographic criteria. Mitral E/e' decreased from 16.4 [14.2-18.3] on day 1 to 13.1 [11.3-15.1] by day 7 (p < 0.01), while lateral e' increased from 3.3 [2.9-3.7] to 4.1 [3.6-4.6] cm/s (p = 0.009), consistent with improving relaxation. At day 7, infants with hsPDA (6/20) had higher mitral E/A ratios (1.08 [1.01-1.14] vs. 0.95 [0.89-1.00], p = 0.04), elevated E/e' (9.1 [8.4-10.0] vs. 6.4 [5.7-7.1], p < 0.01). Indexed LA volume was also larger in the hsPDA group. Larger PFO diameter (≥ 2.5 mm) showed a trend toward lower LA volume indices and E/e', although differences were not statistically significant. Rapid diastolic adaptation occurs during the first postnatal week in VLBW infants. hsPDA is linked to increased LA pressure and impaired relaxation. Early functional echocardiography may aid in guiding targeted neonatal care.

Indexed as

Heart VentriclesInfant, PrematureInfant, Very Low Birth WeightVentricular Function, LeftDiastoleEchocardiographyFemaleGestational AgeHumansInfant, NewbornMaleProspective StudiesDiastolic functionEchocardiographyLeft atriumPreterm infantsTissue doppler imaging

Identifiers

PMID40731177
PMCPMC12945902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.