ArticleDiscover oncology2025
Different inhibitory effect of a neuropilin-1 monoclonal antibody on different types of hepatocellular carcinoma.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
As a co-receptor for vascular endothelial growth factor, neuropilin receptor type-1 (NRP-1) plays a crucial role in tumor angiogenesis, growth, and metastasis, and is regarded as a promising target for cancer molecular imaging and therapy. However, few data on inhibitory effect of an anti-NRP-1 monoclonal antibody on HCC with different NRP-1 expression levels have been reported. This study aimed to investigate inhibitory effect of an anti-NRP-1 monoclonal antibody (A6-11-26) on different types of HCC, with a view to further understanding the role of A6-11-26 in HCC. Three different types of HCC cell lines (Bel-7402, SMMC-7721 and HepG2) were conducted in this study. MTT, colony formation test, cell morphology, and flow cytometry were used to assess the inhibitory effect of A6-11-26 on three HCC cell lines. The in vivo growth inhibitory effect of A6-11-26 was evaluated in mice xenograft models bearing three HCC cell lines respectively. Immunohistochemistry analyses was performed to characterize the expressions of vascular endothelial growth factor receptor (VEGFR) and NRP-1 in HCC tissues after A6-11-26 administration. A6-11-26 displayed to inhibit the proliferation, migration and apoptosis of HCC cells in vitro and tumor growth in vivo. The inhibitory effect of A6-11-26 was dose-dependent and dependent on the level of NRP-1 expression. The decreasing expressions of VEGFR and NRP-1 in HCC tissues after A6-11-26 treatment had also dose-dependent and NRP-1 expression characteristics. Taken together, an anti-NRP-1 monoclonal antibody (A6-11-26) can inhibit HCC growth through decreasing NRP-1 and VEGFR expression accordingly with NRP-1 expression characteristics, suggesting that A6-11-26 may be a potential targeted medicine for HCC with high NRP-1 expression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.