ArticleNature metabolism2025
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts.
Abstract read
In one paragraph
Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Targeting the cancer metabolism-immunity interface: update and perspectives.Experimental hematology & oncology · 2026Review
- Decoding cancer across scales with metabolomics.Nature reviews. Cancer · 2026Review
- Harnessing PDX and PDX 2.0: the next-generation paradigm for precision oncology and translational breakthroughs.Molecular cancer · 2026Review
- The Five-Decade Journey of Small Cell Lung Cancer.Cancer communications (London, England) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Aparna D Rao *Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ling Cai *Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Marelize SnymanDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Rachel E WalsdorfDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xiangyi LiChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sophia N WixDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-7467-4185
Gabrielle GardDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-8589-5496
Ariel B BrownDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-5634-2910
Juliana KimDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-6634-4525
Joao Santos PatricioChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0001-7045-4532
Sarah MuhChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Misty Martin SandovalChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Lauren G ZachariasChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kristen A HeimdalChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Wen GuChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-3003-8945
Jade HomsiDepartment of Medical Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Brittny TillmanDepartment of Otolaryngology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Rohit SharmaDepartment of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Travis W VandergriffDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ashley SolmonsonChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Brandon FaubertChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-2886-886X
Thomas P MathewsChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-9355-8243
Sean J MorrisonChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Ralph J DeBerardinisChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. Ralph.DeBerardinis@UTSouthwestern.edu.ORCID http://orcid.org/0000-0002-2705-7432
Jennifer G GillDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Jennifer.Gill@UTSouthwestern.edu.ORCID http://orcid.org/0000-0001-7167-7359
Funding
UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HEYMACH, JOHN V. · 1996 to 2024
$57.4MMichigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9MUT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7MUT Southwestern Center for Translational MedicineUL1TR003163 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2021 to 2025
$39.3MUniversity of Texas Southwestern Medical Center SPORE in Kidney CancerP50CA196516 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Payal Kapur, Payal Kapur · 2016 to 2026
$24.7MMetabolic Regulators of Tumor Growth and ProgressionR35CA220449 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI RALPH J DEBERARDINIS · 2017 to 2026
$9.4MUT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4MConstruction of A Lung Cancer Preclinical Model Cross-comparison PlatformR01CA285336 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Ling Cai · 2024 to 2026
$3.1MThe Metabolic Regulation of Melanoma MetastasisU01CA228608 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MORRISON, SEAN J · 2019 to 2023
$2.9MDermatology Research Training ProgramT32AR065969 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI PONCIANO D CRUZ, Tamia Alisha Harris-Tryon · 2014 to 2026
$1.6MInvestigating the role of GAPDHS in melanoma metabolism and metastasisK08CA279757 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Jennifer Gibson Gill · 2023 to 2026
$1.0MCancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RP180778Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RP210041Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RP240494Department of Health | National Health and Medical Research Council (NHMRC) 2038731Dermatology Foundation (DF) N/ADoris Duke Charitable Foundation (DDCF) 2023-0237Howard Hughes Medical Institute (HHMI) N/ANCATS NIH HHS UL1 TR002240NCATS NIH HHS UL1 TR003163NCI NIH HHS K08 CA279757NCI NIH HHS P30 CA142543NCI NIH HHS P50 CA070907NCI NIH HHS P50 CA196516NCI NIH HHS R01 CA285336NCI NIH HHS R35 CA220449NCI NIH HHS U01 CA228608NIAMS NIH HHS T32 AR065969NIDDK NIH HHS P30 DK127984U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 1K08CA279757U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 2P50CA196516U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 5P50CA070907U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R01CA285336U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) R35CA220449U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) U01CA228608U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) T32AR065969-08Victorian Cancer Agency (VCA) N/A
Abstract
Patient-derived xenografts (PDXs) are frequently used as preclinical models, but their recapitulation of tumour metabolism in patients has not been closely examined. We developed a parallel workflow to analyse [U-
Indexed as
HeterograftsMelanomaNeoplasmsAnimalsCitric Acid CycleGlucoseGlycolysisHumansMetabolomeMetabolomicsMicePhenotypeGlucose
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.