Isolation and characterisation of Klebsiella pneumoniae bacteriophages vB_Kpn_Lilla1 and vB_Kpn_Lilla2.

Timothy Martin, Liana Theodoridis, Emma Stent, Julia Lilla, Steve Petrovski

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Article in Archives of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Timothy Martin *Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Melbourne, VIC, 3086, Australia.

Liana Theodoridis *Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Melbourne, VIC, 3086, Australia.

Emma StentDepartment of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Melbourne, VIC, 3086, Australia.

Julia LillaDepartment of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Melbourne, VIC, 3086, Australia.

Steve PetrovskiDepartment of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University, Melbourne, VIC, 3086, Australia. steve.petrovski@latrobe.edu.au.ORCID http://orcid.org/0000-0002-6304-6853

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Klebsiella pneumoniae is an opportunistic pathogen that is commonly associated with pulmonary infections. It is of particular concern due to its increasing resistance to antibiotics, particularly carbapenem. Alternative treatments for these bacterial infections are required, and phage application is an attractive option. In this study, we isolated two novel Klebsiella pneumonia bacteriophages from wastewater, vB_Kpn_Lilla1 and vB_Kpn_Lilla2, both of which have lytic activity against Klebsiella oxytoca and Klebsiella michiganensis. Genome sequencing and phylogenetic analysis revealed that both phages belong to the family Straboviridae, with vB_Kpn_Lilla1 belonging to the genus Jiaodavirus and vB_Kpn_Lilla2 belonging to the genus Slopekvirus. Growth kinetics showed an effective reduction of K. pneumoniae populations when infected with either phage.

Indexed as

BacteriophagesKlebsiella pneumoniaeGenome, ViralKlebsiella InfectionsPhylogenyWastewaterWastewater

Identifiers

PMID40731104

DOI10.1007/s00705-025-06374-7

PMCPMC12307530

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.