Evidence map›Paper›PMID 40731012›Full record

ArticleScientific reports2025

Comparative study of gastric microbiota between patients with autoimmune gastritis and those with atrophic gastritis.

Kengo Tokunaga, Sawako Miyoshi, Fuhito Hojo, Hideo Yonezawa, Yosuke Ida, Kentaro Oka, Motomichi Takahashi, Shigeru Kamiya, Jun Miyoshi, Tadakazu Hisamatsu and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kengo TokunagaDepartment of Preventive Medicine, Kyorin University School of Medicine, Shinkawa 6-20-2, Mitaka, Tokyo, 181-8611, Japan. kentoku@ks.kyorin-u.ac.jp.
Sawako MiyoshiDepartment of Preventive Medicine, Kyorin University School of Medicine, Shinkawa 6-20-2, Mitaka, Tokyo, 181-8611, Japan.
Fuhito HojoGraduate School of Medicine, Institute of Laboratory Animals, Kyorin University, Shinkawa 6-20-2, Mitaka, Tokyo, 181-8611, Japan.
Hideo YonezawaDepartment of Microbiology, Tokyo Dental College, Tokyo, Japan.
Yosuke IdaDepartment of Preventive Medicine, Kyorin University School of Medicine, Shinkawa 6-20-2, Mitaka, Tokyo, 181-8611, Japan.
Kentaro OkaR&D Division, Research Department, Miyarisan Pharmaceutical Co., Ltd., Saitama City, Saitama, 331-0804, Japan.
Motomichi TakahashiR&D Division, Research Department, Miyarisan Pharmaceutical Co., Ltd., Saitama City, Saitama, 331-0804, Japan.
Shigeru KamiyaR&D Division, Research Department, Miyarisan Pharmaceutical Co., Ltd., Saitama City, Saitama, 331-0804, Japan.
Jun MiyoshiDepartment of Gastroenterology and Hepatology, Kyorin University School of Medicine, Shinkawa 6-20-2, Mitaka, Tokyo, 181-8611, Japan.
Tadakazu HisamatsuDepartment of Gastroenterology and Hepatology, Kyorin University School of Medicine, Shinkawa 6-20-2, Mitaka, Tokyo, 181-8611, Japan.
Takako OsakiDepartment of Preventive Medicine, Kyorin University School of Medicine, Shinkawa 6-20-2, Mitaka, Tokyo, 181-8611, Japan. osaki@ks.kyorin-u.ac.jp.

Funding

a Grant-in-Aid for Scientific Research (KAKENHI) 20K08365a Grant-in-Aid for Scientific Research (KAKENHI) 24K11176
6 · The paper itself

Abstract

Fundamental treatments for autoimmune gastritis (AIG) have not yet been established; thus, analyzing AIG pathogenesis in detail to obtain useful information for prognosis prediction and treatment is crucial. This study explored bacteria involved in AIG pathogenesis by focusing on the gastric microbiota composition. Gastric biopsy tissues were collected endoscopically from the gastric corpus and antrum of patients with AIG and chronic gastritis. Total DNA was extracted from gastric biopsy specimens and used for 16S rRNA gene amplicon sequencing analysis. Principal coordinate analysis of diversity using the weighted UniFrac distance revealed that following Helicobacter pylori eradication, the gastric bacterial composition of patients with AIG differed significantly from that of patients with chronic gastritis, exhibiting decreased Shannon index, Pielou's evenness, and Simpson index of alpha diversity. The gastric microbiota of patients with AIG was characterized by an increased abundance of the genus Streptococcus and a reduced abundance of the genus Prevotella compared with that of patients with chronic gastritis.

Indexed as

Autoimmune DiseasesGastritisGastritis, AtrophicGastrointestinal MicrobiomeAdultAgedFemaleGastric MucosaHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16SAutoimmune gastritisChronic gastritisGenus PrevotellaGenus StreptococcusHelicobacter pyloriMicrobiota

Identifiers

PMID40731012
PMCPMC12307792

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