Evidence map›Paper›PMID 40731006›Full record

ArticleBMC public health2025

High-risk human papillomavirus testing for underscreened populations: cost-effectiveness and affordability in three country settings.

Marat Sultanov, Geertruida H de Bock, Jaap A R Koot, Janine de Zeeuw, Marcel J W Greuter, Fengming Pan, Jelle Stekelenburg, Jogchum J Beltman, Marlieke de Fouw, Carolyn Nakisige and 9 more

Abstract read
In one paragraph

Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Marat SultanovDepartment of Health Sciences, Global Health Unit, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. m.sultanov@umcg.nl.ORCID http://orcid.org/0000-0002-5746-811X
Geertruida H de BockDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID http://orcid.org/0000-0003-3104-4471
Jaap A R KootDepartment of Health Sciences, Global Health Unit, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID http://orcid.org/0000-0002-6933-0302
Janine de ZeeuwDepartment of Health Sciences, Global Health Unit, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID http://orcid.org/0000-0002-7979-9366
Marcel J W GreuterDepartment of Radiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID http://orcid.org/0000-0001-5721-9159
Fengming PanDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID http://orcid.org/0000-0003-4751-5012
Jelle StekelenburgDepartment of Health Sciences, Global Health Unit, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID http://orcid.org/0000-0002-2732-6620
Jogchum J BeltmanDepartment of Gynecology, Leiden University Medical Center, Leiden University, Leiden, Netherlands.
Marlieke de FouwDepartment of Gynecology, Leiden University Medical Center, Leiden University, Leiden, Netherlands.ORCID http://orcid.org/0000-0002-4488-4886
Carolyn NakisigeUganda Cancer Institute, Kampala, Uganda.ORCID http://orcid.org/0000-0002-1497-8056
Johnblack K KabukyeUganda Cancer Institute, Kampala, Uganda.ORCID http://orcid.org/0000-0002-7864-1858
Ezra AnechoUganda Cancer Institute, Kampala, Uganda.
Naheed NazrulFriendship NGO, Dhaka, Bangladesh.ORCID http://orcid.org/0000-0003-3906-3490
Mosamat U KulsumFriendship NGO, Dhaka, Bangladesh.
Aminur RahmanInternational Centre for Diarrhoeal Disease Research (icddr,b), Dhaka, Bangladesh.ORCID http://orcid.org/0000-0003-1434-3883
Marek MajdanDepartment of Public Health, Faculty of Health Care and Social Work, Institute for Global Health and Epidemiology, Trnava University, Trnava, Slovak Republic.ORCID http://orcid.org/0000-0001-8037-742X
Juliana MelichováDepartment of Public Health, Faculty of Health Care and Social Work, Institute for Global Health and Epidemiology, Trnava University, Trnava, Slovak Republic.ORCID http://orcid.org/0000-0003-4920-0778
Jaroslava SokolováDepartment of Laboratory Medicine, Faculty of Health Care and Social Work, Center for Microbiology and Infection Prevention, Trnava University, Trnava, Slovak Republic.
Jurjen van der SchansDepartment of Health Sciences, Global Health Unit, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.ORCID http://orcid.org/0000-0001-6170-1191

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe high-risk human papillomavirus (hrHPV)-based screening recommended by the World Health Organization is expected to lead to worldwide reduction of the cervical cancer burden, but the countries burdened most by cervical cancer also struggle with the costs of transitioning to this approach. Country-specific evaluations are needed to inform policymakers on implementation of hrHPV-based screening for their setting. Following initial implementation in Uganda, Bangladesh and Slovakia focused on underscreened women in the PRESCRIP-TEC project, we investigated the potential cost-effectiveness and affordability of hrHPV-based screening strategies.

methodsCountry-specific model-based cost-effectiveness and budget impact analyses were conducted for the three countries, comparing the PRESCRIP-TEC strategy with the existing screening strategy in each setting. Data from initial project implementation informed the relevant model parameters.

resultsThe PRESCRIP-TEC strategy resulted in disability-adjusted life year (DALY) gains in all three countries. The cervical cancer incidence rate was reduced by a third for Uganda, 15% for Bangladesh and 11% for Slovakia. The incremental cost-effectiveness ratios were UGX 0.56 million per DALY for Uganda (I$ 475), BDT 76 thousand per DALY for Bangladesh (I$ 1698) and EUR 1782 (I$ 3637) per DALY for Slovakia. Substantial additional funding will be required to enable implementation, particularly in relation to the initial start-up costs.

conclusionsThe provided estimates can serve to inform policymakers and researchers in the context of implementing hrHPV-based screening in diverse settings.

Indexed as

Early Detection of CancerMass ScreeningPapillomavirus InfectionsUterine Cervical NeoplasmsAdultBangladeshCost-Benefit AnalysisDisability-Adjusted Life YearsFemaleHuman Papillomavirus VirusesHumansMiddle AgedSlovakiaUgandaBudget impactCervical cancerCost-effectivenessEconomic evaluationHigh-risk human papillomavirusScreening

Identifiers

PMID40731006
PMCPMC12305891

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.