Evidence map›Paper›PMID 40730956›Full record

ArticleBMC ophthalmology2025

Effects of matrix metalloproteinase inhibition in cultured human Tenon's capsule fibroblasts.

Na Hyun Kim, Kyung Eun Han, Roo Min Jun, Seongsoo Sohn, Changwon Kee, Wool Suh

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Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Na Hyun KimDepartment of Ophthalmology, Institute of Ophthalmology and Optometry, Ewha Womans University College of Medicine, Ewha Womans University Mokdong Hospital, Seoul, South Korea.
Kyung Eun HanDepartment of Ophthalmology, Institute of Ophthalmology and Optometry, Ewha Womans University College of Medicine, Ewha Womans University Mokdong Hospital, Seoul, South Korea.
Roo Min JunThe Institute of Ophthalmology and Optometry, Department of Ophthalmology, Ewha Womans University College of Medicine, Ewha Womans University Seoul Hospital, Seoul, South Korea.
Seongsoo SohnDepartment of Ophthalmology, Research Institute for Future Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Changwon KeeDepartment of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, Seoul, South Korea.
Wool SuhDepartment of Ophthalmology, Institute of Ophthalmology and Optometry, Ewha Womans University College of Medicine, Ewha Womans University Mokdong Hospital, Seoul, South Korea. swophth@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to compare the characteristics of anterior and posterior human Tenon's capsule fibroblasts and determine the effect of matrix metalloproteinase (MMP) inhibition on cultured human Tenon's capsule fibroblasts.

methodsTissues obtained from the anterior and posterior Tenon's capsules were partially incised, cultured, and subjected to microarray analysis. Electrophoresis was performed on the cells treated with Ilomastat (MMP-9 inhibitor), and collagen 1, 3, and 6. Antibodies against transforming growth factor-beta (TGF-β) and vimentin were used as probes to compare the expression levels.

resultsThere were no differences between anterior and posterior Tenon's capsule fibroblasts in the microarray. Western blot analysis showed similar expression of collagen 1, 3, and 6, TGF-β, and vimentin between anterior and posterior Tenon's capsule fibroblast. Ilomastat did not affect the proliferation of cultured human Tenon's capsule.

conclusionsNo differences in characteristics were observed between anterior and posterior Tenon's capsule fibroblasts, and inhibition of MMPs did not affect the proliferation of cultured human Tenon's capsule fibroblasts.

Indexed as

FibroblastsMatrix Metalloproteinase InhibitorsTenon CapsuleBlotting, WesternCell ProliferationCells, CulturedHumansHydroxamic AcidsIndolesTransforming Growth Factor betaVimentinHydroxamic AcidsilomastatIndolesMatrix Metalloproteinase InhibitorsTransforming Growth Factor betaVimentinAntimetaboliteMatrix metalloproteinaseTenon’s capsule fibroblast

Identifiers

PMID40730956
PMCPMC12308980

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.