ArticleLung2025
Lung Tissue Compliance Interacts with Smooth Muscle and Drives Hyperresponsiveness in Mice with Experimental Asthma.
Article in Lung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
introductionA recent study on BALB/c and C57BL/6 mice demonstrated a clear lack of association between the in vivo response to nebulized methacholine and the degree of airway narrowing ex vivo in a model of asthma induced by a daily exposure to house dust mite over 10 consecutive days. This finding raises the question of which factors determine the methacholine response in vivo.
methodsHerein, multiple linear regression analyses were used to determine which baseline physiological characteristics are associated with the methacholine response.
resultsAmong the 10 baseline characteristics studied, and depending on how the methacholine response was monitored during a concentration-response, lung tissue compliance was the most commonly and robustly associated with the methacholine response. Inspiratory capacity was the second most frequently associated.
conclusionThese results suggest that lung tissue compliance and inspiratory capacity may be two important determinants of the methacholine response in BALB/c and C57BL/6 mice with and without experimental asthma.
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