ReviewNature microbiology2025
Evolution of antifungal resistance in the environment.
Review in Nature microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Directed biosynthesis of the designer peptidyl nucleoside antibiotics featuring a simplified azetidine-containing moiety.Synthetic and systems biotechnology · 2027Article
- Multidrug antifungal resistance and clinical outcomes in fungal keratitis: a prospective study in a South Indian population.Eye (London, England) · 2026Article
- mSphere of Influence: The age of antifungal resistance.mSphere · 2026Article
- A review on fungal pathogens in the One Health framework: connecting plant, animal, and human health.Archives of microbiology · 2026Review
- The putative mitochondrial serine protease Pim1 regulates azole tolerance through redox homeostasis in Aspergillus fumigatus.Archives of microbiology · 2026Article
- Antifungal activity and potential mechanisms of two new bafilomycin analogues from Streptomyces sp. TH30 against tomato early blight.Pest management science · 2026Article
- Climate change and antimicrobial resistance.Nature reviews. Microbiology · 2026Review
- Discovery of novel uridine-based chitin synthase inhibitors: Design, synthesis and structure-activity relationships.Pest management science · 2026Article
- Repurposing FDA-Approved Drugs to Inhibit Fungal PPTases for Broad-Spectrum Synergy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Amino acid substitutions at the G118 hotspot in dihydroorotate dehydrogenase confer olorofim resistance inMicrobiology spectrum · 2026Article
- Repurposed Aripiprazole-Loaded Hyaluronic Acid/Ceramide/Terpene Nanosponge as a Bioadhesive Topical Delivery System for CutaneousPharmaceuticals (Basel, Switzerland) · 2026Article
- Antifungal resistance: from classical mechanisms to the expanding role of acetyltransferases.Journal of biomedical science · 2026Review
- Innovation in antifungal therapy.EMBO molecular medicine · 2026Review
- Unraveling the mechanism of action of the PepGAT peptide against Candida albicans through proteomics approaches.Scientific reports · 2026Article
- Agricultural fungicides shape soil and sediment reservoirs of multidrug-resistant fungi.Nature communications · 2026Article
- Environmentally Safe and Just Pharmacy: A Framework and Action Plan for Operating within the Earth System Boundary for Novel Entities.Environmental science & technology · 2026Article
- Genotype-Phenotype Relationships in Azole-ResistantJournal of fungi (Basel, Switzerland) · 2026Review
- Metalloids: Semi as Metals yet Full of Antimicrobial Potential.ChemMedChem · 2026Review
- Aspergillosis: An Update on Epidemiology, Risk Factors, Diagnosis, Susceptibility, and Treatment.Journal of fungi (Basel, Switzerland) · 2026Review
- Climate change-driven geographical shifts iniScience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The emergence of drug-resistant fungal infections in agriculture and healthcare settings has caused severe implications for food security, public health and natural environments. They pose a substantial hazard for at-risk patient populations who often acquire serious and sometimes life-threatening infections. With the increasing use of fungicides in the environment, acquisition of resistance to fungicides and antifungal drugs pose a risk to health. In this Review we summarize the evolution, emergence and expansion of fungicide and antifungal drug resistance globally. We discuss different antifungals and fungicides, their modes of action and resistance mechanisms. Furthermore, we outline the current state of knowledge about the emergence and expansion of resistant fungi in hotspots and coldspots in the environment. Finally, we summarize alternative options and future directions in reducing antifungal resistance.
Indexed as
Identifiers
40730910What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.