Evidence map›Paper›PMID 40730899›Full record

ArticleNature immunology2025

Mammary intraepithelial lymphocytes and intestinal inputs shape T cell dynamics in lactogenesis.

Abigail Jaquish, Eleni Phung, Xutong Gong, Pilar Baldominos, Silvia Galván-Peña, Ian Magill, Isabelle Bursulaya, Eleonora Marina, ImmgenT consortium, Kerri Bertrand and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Tissue-resident CD8Nature immunology · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Abigail JaquishNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-2250-1028
Eleni PhungNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-1414-748X
Xutong GongDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3295-076X
Pilar BaldominosDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-4988-6290
Silvia Galván-PeñaDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Ian MagillDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0009-1280-3365
Isabelle BursulayaNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Eleonora MarinaDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
ImmgenT consortium
Kerri BertrandDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Christina ChambersDepartment of Pediatrics, University of California, San Diego, La Jolla, CA, USA.
Andrés R Muñoz-RojasDepartment of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.
Judith AgudoDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3576-3169
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6110-4626
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1172-6555
Deepshika RamananNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA. dramanan@salk.edu.ORCID http://orcid.org/0000-0003-1029-8042

Funding

Viral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Alan Saghatelian · 1985 to 2026
$82.8M
ImmGen: Gene Expression and Regulation in Immune CellsR24AI072073 · NIAID · JOSLIN DIABETES CENTER · PI CHRISTOPHE O. BENOIST · 2007 to 2026
$28.5M
Pathways in Biological Sciences Training ProgramT32GM133351 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew Daugherty, Randolph Y. Hampton · 2020 to 2026
$9.9M
San Diego Nathan Shock CenterP30AG068635 · NIA · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI SHADEL, GERALD · 2020 to 2024
$6.0M
Treg cell diversity and homeostatic controlR01AI150686 · NIAID · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O. · 2020 to 2024
$2.6M
Spectral Configured Bigfoot Sorter for Salk Institute Flow Cytometry CoreS10OD034268 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI O'CONNOR, CAROLYN PEY-MIN · 2023 to 2023
$724k
BD FACSAria Fusion for Flow Cytometry Core FacilityS10OD023689 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2018 to 2018
$530k
Damon Runyon Cancer Research Foundation (Cancer Research Fund of the Damon Runyon-Walter Winchell Foundation) Dale F Frey AwardNCI NIH HHS P30 CA014195NIAID NIH HHS R01 AI150686NIAID NIH HHS R24 AI072073NIA NIH HHS P30 AG068635NIGMS NIH HHS T32 GM133351NIH HHS S10 OD023689NIH HHS S10 OD034268U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01-AI150686
6 · The paper itself

Abstract

Pregnancy brings about profound changes in the mammary gland to prepare for lactation, yet immunocyte changes that accompany this rapid remodeling are incompletely understood. We comprehensively analyzed mammary T cells, revealing a marked increase in CD4

Indexed as

CD4-Positive T-LymphocytesCD8-Positive T-LymphocytesIntestinal MucosaIntraepithelial LymphocytesLactationMammary Glands, AnimalMammary Glands, HumanAnimalsCell MovementFemaleHumansMiceMice, Inbred C57BLPregnancyReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID40730899
PMCPMC12369998

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.