Evidence map›Paper›PMID 40730890›Full record

ReviewMedical oncology (Northwood, London, England)2025

Exploring the therapeutic role of carnosol in cancer: from molecular insights to clinical promise.

Ali Nakhaei, Sadaf Afshari, Arezoo Omidkhoda, Elmira Mohtashami, Mohammad Mahdi Vahedi, Seyed Sajad Ahmadi, Mahsa Jalali, Amir R Afshari

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ali Nakhaei *Student Research Committee, MMS.C., Islamic Azad University, Mashhad, Iran.
Sadaf Afshari *Student Research Committee, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Arezoo OmidkhodaStudent Research Committee, MMS.C., Islamic Azad University, Mashhad, Iran.
Elmira MohtashamiSchool of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Mahdi VahediDepartment of Pharmacology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Seyed Sajad AhmadiDepartment of Ophthalmology, Alzahra Eye Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.
Mahsa JalaliDepartment of Basic Sciences, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.
Amir R AfshariDepartment of Basic Sciences, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran. Amirreza.afshari2@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer is a leading cause of mortality worldwide, triggering healthcare system challenges and emphasizing the need for targeted treatment methods. Traditional cancer treatments can be ineffective, have long response times, and cause significant side effects that lower patients' quality of life. Recently, attention has switched to natural compounds with anticancer properties. Carnosol, a phenolic diterpene found in rosemary and sage, is a promising alternative. Carnosol has diverse biological effects, including influencing cellular signaling pathways for proliferation, apoptosis, inflammation, and oxidative stress. Recent research has revealed its anticancer properties, preventing tumor growth and progression in breast, prostate, colorectal, and glioblastoma multiforme. Carnosol's potential as a multi-targeted therapeutic drug is supported by these findings, paving the way for its clinical usage in cancer treatment.

Indexed as

AbietanesAntineoplastic Agents, PhytogenicNeoplasmsAnimalsHumansAbietanesAntineoplastic Agents, PhytogeniccarnosolBreast cancerCarnosolColorectal cancerGlioblastomaProstate cancer

Identifiers

PMID40730890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.