Evidence map›Paper›PMID 40730886›Full record

ArticleCommunications biology2025

CG>TG mutation frequency as negative predictor of homologous recombination deficiency in ovarian and breast cancer.

Eva Romanovsky, Michael Menzel, Klaus Kluck, Susanne Beck, Markus Ball, Peter Schirmacher, Daniel Kazdal, Albrecht Stenzinger, Jan Budczies

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eva RomanovskyInstitute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-0059-1977
Michael MenzelInstitute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4129-4741
Klaus KluckInstitute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0009-0001-1000-8052
Susanne BeckInstitute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-2652-8722
Markus BallInstitute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-2312-8360
Peter SchirmacherInstitute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Daniel KazdalInstitute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-8187-3281
Albrecht Stenzinger *Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-1001-103X
Jan Budczies *Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. jan.budczies@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-6668-5327

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Homologous recombination deficiency (HRD) is a predictive biomarker for PARP inhibition and platinum-based chemotherapy. While copy number alteration-based scores such as HRDsum = LST + TAI + LOH are included in therapy approvals, single base substitutions (SBS) are underinvestigated as predictors of HRD. WES data of the TCGA pan-cancer cohort and an in-house ovarian cancer cohort were annotated by alterations in BRCA1/2 and additional genes causative of HRD. Using this reference, the new biomarker f

Indexed as

Breast NeoplasmsHomologous RecombinationMutationMutation RateOvarian NeoplasmsBiomarkers, TumorBRCA2 ProteinFemaleHumansBiomarkers, TumorBRCA2 Protein

Identifiers

PMID40730886
PMCPMC12307739

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.