ReviewCell death & disease2025
The complex conundrum of Merkel cell carcinoma cellular ancestry.
Review in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- No Association Between Radiation Dose and Clinical Outcomes in Merkel Cell Carcinoma in the Veteran Population.Advances in radiation oncology · 2026Article
- The human skin virome: Ecological dynamics, aberrant profiles, and therapeutic opportunities.Cell host & microbe · 2026Review
- EmergingFrontiers in cell and developmental biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Merkel cell carcinoma (MCC) is a rare but lethal skin neoplasm, caused, in approximately 80% of cases, by the genomic integration of Merkel cell polyomavirus (MCPyV) and the expression of viral oncoproteins small T (sT) and large T (LT) antigens. Virus-negative MCCs exhibit extensive UV-induced mutations. Although there is a growing understanding of MCC pathogenesis, the cellular origin of MCC remains a topic of intense investigation and debate. In this perspective, we will provide a description and discussion of the current theories regarding the cellular ancestry of MCC. The most recent findings point in favor of a potential epithelial origin of MCC. MCPyV integration likely occurs in an epithelial precursor cell prior to MCPyV-driven clonal expansion, while the same originating cell type may undergo a specific molecular switch that drives neuroendocrine differentiation, leading to UV-mutated, virus-negative MCCs. Identifying the cellular origin of MCC is crucial for developing accurate pre-clinical models and advancing clinical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.