ReviewJournal of thrombosis and thrombolysis2025
Management of cancer-associated venous thromboembolism: Perspectives on optimizing current therapeutics with a focus on factor XI inhibition.
Review in Journal of thrombosis and thrombolysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- The New Cardio-Oncology Frontier in Hematologic Cancers: Cardiovascular Toxicities of CAR-T Cells and Bispecific T-Cell Engagers.Journal of clinical medicine · 2026Review
- Edoxaban for treatment of cancer-related isolated distal deep vein thrombosis: harnessing evidence, seeking equipoise.Journal of thrombosis and thrombolysis · 2026Article
- Thrombosis in patients with cancer: challenges and advances.Journal of thrombosis and thrombolysis · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer-associated thrombosis (CAT) encompasses manifestations of deep venous thrombosis and/or pulmonary embolism occurring during the evolution of cancer. CAT represents one of the major cardiovascular complications associated with cancer and anti-cancer treatments, and the second leading cause of death after cancer progression. The rate of venous thromboembolism (VTE) recurrence is augmented in patients with cancer, together with the risk of bleeding, when compared with subjects without malignancy. Thus, decisions on optimal anticoagulation strategy should carefully balance both thrombotic and bleeding risk. While low-molecular weight heparins and direct oral anticoagulants now represent the standard-of-care in patients with cancer, newer pharmacologic compounds able to prevent VTE recurrence while minimizing the hemorrhagic risk are needed, and currently under investigation. In particular, factor XI inhibitors have emerged as potentially safe drugs in this highly vulnerable population, although results from dedicated clinical trials are waited to confirm this hypothesis. This review aims to summarize current management, controversies, and latest developments in pharmacotherapeutic approaches for patients with CAT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.