Evidence map›Paper›PMID 40730707›Full record

ReviewJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2025

Key markers and detection methods for evaluating platelet dysfunction in mechanical circulatory support devices.

Zhenling Wei, Zhuo Li, Wangwang Su, Longhui Cheng, Liudi Zhang

Abstract readReview
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In one paragraph

Review in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhenling WeiArtificial Organ Technology Laboratory, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, 215006, China. 20225229107@stu.suda.edu.cn.
Zhuo LiArtificial Organ Technology Laboratory, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, 215006, China.
Wangwang SuArtificial Organ Technology Laboratory, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, 215006, China.
Longhui ChengArtificial Organ Technology Laboratory, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, 215006, China.
Liudi ZhangArtificial Organ Technology Laboratory, School of Mechanical and Electrical Engineering, Soochow University, Suzhou, 215006, China. liudi@suda.edu.cn.ORCID http://orcid.org/0000-0003-3803-863X

Funding

National Natural Science Foundation of China 31700817
6 · The paper itself

Abstract

Mechanical circulatory support devices (MCSDs) have emerged as life-saving interventions for patients with end-stage heart failure. However, the non-physiological shear stress (NPSS) generated by MCSDs is a known precipitant of platelet dysfunction, augmenting risks of thrombotic and bleeding complications. Addressing this issue necessitates innovative approaches to attenuate platelet dysfunction, thereby enhancing the safety of MCSDs. This review synthesizes knowledge pertaining to the normal hemostatic process, the implications of NPSS on platelet function, the array of markers extensively employed to assess platelet dysfunction, and relevant detection assays, within the scope of MCSDs-related hemocompatibility. NPSS can induce platelet activation and receptor shedding, causing both thrombosis and bleeding. The use of fluorescence-activated cell sorting (FACS) to monitor changes in markers, including platelet surface receptors, P-selectin, platelet monocyte aggregation (PMA), platelet-derived microparticles (PDMPs), and phosphatidylserine (PS), Enzyme-Linked Immunosorbent Assay (ELISA) for platelet secretion analysis, and the modified prothrombinase platelet activity state (PAS) for thrombin assessment, are central to investigating these consequences. PS and thrombin, particularly, present unique responses to NPSS, underscoring their potential as targeted markers for platelet dysfunction research. Additionally, assessments of morphological shifts and platelet aggregation, through scanning electron microscopy (SEM) and fluorescence microscopy provide a more visualized evaluation of NPSS-mediated platelet dysfunction. Combining distinct markers and assays is essential to understanding and potentially mitigating NPSS-induced complications in MCSD therapy. Future research should focus on validating NPSS-specific biomarkers, standardizing detection methodologies, and elucidating interactions with MCSD-induced hemolysis and coagulopathy, ultimately improving safety and efficacy.

Indexed as

Blood Platelet DisordersBlood PlateletsHeart-Assist DevicesHeart FailureBiomarkersHumansPlatelet ActivationPlatelet Function TestsBiomarkersBleedingMarkersPlatelet dysfunctionShear stressThrombosis

Identifiers

PMID40730707

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.