Evidence map›Paper›PMID 40730637›Full record

ArticleCommunications chemistry2025

Structural molecular details of the endocytic adaptor protein CALM upon binding with phosphatidylinositol 4,5-bisphosphate-containing model membranes.

Andreas Santamaria, Daniel Pereira, Nisha Pawar, Bernard T Kelly, Javier Carrascosa-Tejedor, Mariana Sardo, Luís Mafra, Giovanna Fragneto, David J Owen, Ildefonso Marín-Montesinos and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andreas Santamaria *Institut Laue-Langevin, 71 Avenue des Martyrs, 38042, Grenoble, France.ORCID http://orcid.org/0000-0002-6151-4406
Daniel Pereira *Department of Chemistry, CICECO, University of Aveiro, Aveiro, Portugal.
Nisha PawarCentro de Fı́sica de Materiales (CSIC, UPV/EHU) - Materials Physics Center MPC, Paseo Manuel de Lardizabal 5, San Sebastián, Spain.
Bernard T KellyCambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Javier Carrascosa-TejedorInstitut Laue-Langevin, 71 Avenue des Martyrs, 38042, Grenoble, France.
Mariana SardoDepartment of Chemistry, CICECO, University of Aveiro, Aveiro, Portugal.ORCID http://orcid.org/0000-0003-3208-4387
Luís MafraDepartment of Chemistry, CICECO, University of Aveiro, Aveiro, Portugal.ORCID http://orcid.org/0000-0003-1028-8354
Giovanna FragnetoInstitut Laue-Langevin, 71 Avenue des Martyrs, 38042, Grenoble, France.ORCID http://orcid.org/0000-0002-9896-3387
David J OwenCambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. djo30@cam.ac.uk.ORCID http://orcid.org/0000-0002-8351-6322
Ildefonso Marín-MontesinosDepartment of Chemistry, CICECO, University of Aveiro, Aveiro, Portugal. imarin@ua.pt.ORCID http://orcid.org/0000-0002-4206-2643
Eduardo GuzmánDepartamento de Química-Física, Facultad de Ciencias Químicas, Universidad Complutense, Ciudad Universitaria s/n, Madrid, Spain.ORCID http://orcid.org/0000-0002-4682-2734
Nathan R ZaccaiCambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. nrz20@cam.ac.uk.ORCID http://orcid.org/0000-0002-1476-2044
Armando MaestroCentro de Fı́sica de Materiales (CSIC, UPV/EHU) - Materials Physics Center MPC, Paseo Manuel de Lardizabal 5, San Sebastián, Spain. Armando.maestro@ehu.eus.ORCID http://orcid.org/0000-0002-7791-8130

Funding

Wellcome TrustWellcome Trust (Wellcome) 207455/Z/17/Z
6 · The paper itself

Abstract

Clathrin assembly lymphoid myeloid leukaemia protein (CALM) is involved in the formation of clathrin-mediated endocytic coats by virtue of binding many proteins involved in the process, including clathrin itself and AP2 cargo adaptor complex. CALM is able to specifically recognize the inner leaflet of the plasma membrane by binding the membrane's phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P

Identifiers

PMID40730637
PMCPMC12307879

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.