Evidence map›Paper›PMID 40730566›Full record

ArticleScientific reports2025

The albumin-globulin ratio is associated with periodontitis in American adults: results from the NHANES 2009-2014.

Jiajia Chen, Yamei Li, Xingjin Chen, Xue Jiang, Na Liu, Jukun Song, Zhu Chen

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jiajia ChenSchool of Stomatology, Zunyi Medical University, Zunyi, Guizhou, China.
Yamei LiGuiyang Hospital of Stomatology, Guiyang, Guizhou, China.
Xingjin ChenSchool of Stomatology, Zunyi Medical University, Zunyi, Guizhou, China.
Xue JiangSchool of Stomatology, Zunyi Medical University, Zunyi, Guizhou, China.
Na LiuSchool of Stomatology, Zunyi Medical University, Zunyi, Guizhou, China.
Jukun SongOral & Maxillofacial Surgery Department, Guizhou Medical University, Guiyang, Guizhou, China.
Zhu ChenGuiyang Hospital of Stomatology, Guiyang, Guizhou, China. zhuchen@gzu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It's not clear whether periodontitis and the albumin-to-globulin ratio (AGR) are related. This study intended to determine the association between AGR and periodontitis using the NHANES database. The National Health and Nutrition Examination Survey (NHANES) data from 2009 to 2014 were used in this investigation. The dependent variable was periodontitis, the independent variable was AGR, and the 2012 Eke criteria were used to classify periodontitis. The association between AGR and periodontitis was examined using a multivariate logistic regression model. A total of 9134 participants were included in this study, which was analyzed using multivariate logistic regression and showed a significant negative association between AGR and periodontitis (OR = 0.56; 95% CI, 0.47-0.67, p < 0.0001). Delineation of AGR into quartiles showed that this result persisted. In addition, a threshold nonlinear association between AGR and periodontitis was found, with AGR considered a protective factor at AGR < 1.79 (OR = 0.42; 95% CI, 0.33-0.54, p < 0.0001). This cross-sectional investigation revealed a possible negative correlation between AGR and periodontitis, suggesting that AGR may be a potential biomarker for periodontitis screening and prevention. Future research employing causal methods and longitudinal designs is required to confirm our observations.

Indexed as

PeriodontitisSerum AlbuminSerum GlobulinsAdultAgedBiomarkersCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysUnited StatesBiomarkersSerum AlbuminSerum GlobulinsAlbumin-globulin ratioNHANESPeriodontitis

Identifiers

PMID40730566
PMCPMC12307635

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.