Evidence map›Paper›PMID 40730558›Full record

Articlenpj aging2025

Local radiotherapy for cancer patients is associated with mosaic loss of chromosome Y, a hallmark of male aging.

Takuro Kobayashi, Tsuyoshi Hachiya, Yan Lu, Yoshihiro Ikehata, Toshiyuki China, Haruna Kawano, Masayoshi Nagata, Hisamitsu Ide, Shuji Isotani, Shuko Nojiri and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Takuro KobayashiDepartment of Urology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Tsuyoshi HachiyaData Science and Informatics for Genetic Disorders, Graduate School of Medicine, Juntendo University, Tokyo, Japan. t.hachiya.wa@juntendo.ac.jp.
Yan LuDepartment of Urology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Yoshihiro IkehataDepartment of Urology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Toshiyuki ChinaDepartment of Urology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Haruna KawanoDepartment of Urology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Masayoshi NagataDepartment of Urology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Hisamitsu IdeDepartment of Urology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Shuji IsotaniDepartment of Urology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Shuko NojiriDepartment of Medical Technology Innovation Center, Juntendo University, Tokyo, Japan.
Takuro IwamiLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Shunsuke UchiyamaLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Yasushi OkazakiDiagnostics and Therapeutics of Intractable Diseases, Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Hidewaki NakagawaLaboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.
Takayuki MorisakiBioBank Japan, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Koichi MatsudaBioBank Japan, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Yoichiro KamataniLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Chikashi TeraoLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
Shigeo HorieDepartment of Urology, Graduate School of Medicine, Juntendo University, Tokyo, Japan. shorie@juntendo.ac.jp.

Funding

Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Early-Career Scientists 23K15794
6 · The paper itself

Abstract

Mosaic loss of chromosome Y (mLOY) is the most common somatic mutation in hematopoietic cells of aging men and is linked to cancer risk and mortality. However, its relationship with treatment modalities remains unclear. In 348 prostate cancer patients at Juntendo University Hospital, local radiotherapy was associated with a higher prevalence of mLOY (OR = 2.55, 95% CI: 1.08-6.50, P = 0.04), whereas surgery and endocrine therapy were not. We then examined BioBank Japan data from over 30,000 patients with prostate, lung, colorectal, and gastric cancers. Fixed-effect meta-analysis across these sites showed a significant association between radiotherapy and mLOY (OR = 1.48, 95% CI: 1.11-1.98, P = 0.01). No significant effect heterogeneity was observed across cancer types (Q = 0.36, I² = 0%, P = 0.95). Our findings suggest that radiotherapy may exacerbate genomic instability, indicating a potential vulnerability in certain cancer patients to DNA damage induced by radiation therapy.

Identifiers

PMID40730558
PMCPMC12307641

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.