ArticleClinical nuclear medicine2026
Serial FDG PET/CT Findings in a Patient With Seronegative Neuroborreliosis After Treatment With Rituximab for a Follicular Lymphoma.
Article in Clinical nuclear medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Published data concerning the semiology of neuroborreliosis at FDG PET/CT is scarce, and most reported cases with acute onset of neurological symptoms did not exhibit significant metabolic abnormalities. This 60-year-old man with follicular lymphoma achieved a complete response after 6 cycles of R-CHOP. Two weeks after the last injection, he developed afebrile headaches, neck pain, and paresthesia in his fingers, later followed by a brutal left peripheral facial palsy. FDG PET/CT demonstrated an increased metabolism of the cerebellum and of the cervical spinal cord, which completely resolved after treatment with doxycycline for 3 weeks. This is the first case report exhibiting serial metabolic changes at FDG PET/CT in the central nervous system during the evolution of the disease. This case illustrates the risks of lympho-depletion in patients treated with rituximab and highlights the value of PCR for Borrelia in the CSF in patients with false-negative Borrelia serology.
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