ArticleMedical care2025
Economic Costs of Chronic Pain-United States, 2021.
Article in Medical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07498491 (A Single-Arm Pilot Study Investigating Weighted Blanket Use for Chronic Pain), which is not on this map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Single-Arm Pilot Study Investigating Weighted Blanket Use for Chronic Pain
Who cites it
24 citing papers in PubMed.
- Efficacy of a Remote Person-Centered Intervention Using an eHealth Platform and Telephone Support for Persons With Chronic Pain: Randomized Controlled Trial.JMIR formative research · 2026Trial
- Skill-Based Virtual Reality Therapy in High-Impact Chronic Pain: 2-Year Follow-Up Results From a Secondary Analysis of a Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- CYP2D6-Guided Opioid Therapy for Chronic Pain: A Multi-Center Pragmatic Randomized Controlled Trial.Clinical pharmacology and therapeutics · 2026Article
- Extraction of Pain Severity and Functional Interference From Clinical Narratives Using Domain-Informed Large Language Models: Protocol for a Development and Validation Study.JMIR research protocols · 2026Article
- Exploring the Role of a Noninvasive Audio-Based Therapeutic System for Pain and Symptom Relief: Single-Arm Exploratory Pilot Study.JMIR formative research · 2026Observational
- Chronic pain and oscillatory neuroplasticity: Review on impaired compensatory network responses in resting-state electroencephalography.Brain network disorders · 2026Article
- Personalized Prediction of Acute and Chronic Postsurgical Pain - the role of Multidomain Biosignatures, Machine Learning-Based Integration, and Standardized Outcome Definitions.Current pain and headache reports · 2026Review
- Dopamine transporter gene (Pain reports · 2026Article
- Neuroimaging biomarkers for predicting acupuncture treatment response in chronic pain: a systematic review and meta-analysis protocol.BMJ open · 2026Article
- Tai Chi as a Mind-Body Intervention to Address Chronic Pain in Socially Isolated Older Adults: A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Decentralized Science Supported by Decentralized Finance to Support Pain Research: A Merger of Giants.Current pain and headache reports · 2026Review
- Barettin, a Nonopioid, Nonhallucinogenic Marine Natural Product with Antihyperalgesic Properties Mediated by 5HT2A Inverse Agonism.Journal of natural products · 2026Article
- Brain-Centered Interventions for Nociplastic Pain: From Symptom Management to Pain Resolution.Current pain and headache reports · 2026Review
- Differences in the use of pharmacologic and nonpharmacologic treatments among patients with chronic low back pain between 2017 and 2021: A cross-sectional study of commercial claims.The journal of pain · 2026Article
- Rethinking "Chronic Pain": Patient Perspectives on Developing an Integrated Psychology and Physical Therapy Treatment.Journal of patient experience · 2026Article
- Article
- Use of pain neuroscience education, balance evaluation, and exercise for treating chronic pain with kinesiophobia: a narrative review with clinical recommendations.Frontiers in public health · 2026Review
- Personalized Multimodal and Opioid-Sparing Analgesia for Postoperative Pain Management: Enhancing Recovery and Addressing the Post-Discharge Gap.Journal of pain research · 2026Review
- Reframing Chronicity in Research and Care: A Patient-Informed Framework of Pain Adaptation.Journal of pain research · 2026Article
- Expanding rural access to chronic pain care through nurse care management: A hybrid type I effectiveness-implementation trial protocol.PloS one · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundChronic pain affects more than 1 in 5 adults in the United States. Understanding the economic burden of chronic pain can inform interventions and strategies to improve the quality of life for individuals with chronic pain.
objectiveTo estimate the economic cost of chronic pain in the United States in 2021. RESEARCH
designA cross-sectional analysis estimating the economic costs of chronic pain in 2021. SUBJECTS: In 2021, 6445 (representing 65.8 million) adults with chronic pain were identified using ICD-10-CM codes from the nationally representative Medical Expenditure Panel Survey. MEASURES: Direct medical costs were examined by source of payment and service type. Indirect morbidity costs were estimated from lost productivity from employment disability and missed workdays. We evaluated the economic burden of chronic pain by estimating excess costs among individuals with chronic pain compared with individuals without chronic pain using multivariable regression.
resultsIndividuals with chronic pain had additional total annual medical expenditures of $8068 and additional lost productivity of $2923 per person compared with individuals without chronic pain. In 2021, the economic costs of chronic pain in the United States were estimated to be $722.8 billion, including $530.6 billion in medical care costs and $192.2 billion in lost work productivity.
conclusionsThe economic costs of chronic pain are substantial, resulting in excess health care expenditures and lost productivity costs. These findings highlight the importance of interventions and strategies aimed at providing high-quality, accessible, low-barrier, cost-effective pain care to improve quality of life and reduce disruptions in work among adults with chronic pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.