Evidence map›Paper›PMID 40730349›Full record

ArticleMedical care2025

Economic Costs of Chronic Pain-United States, 2021.

Gery P Guy, Gabrielle F Miller, Jaswinder K Legha, S Michaela Rikard, Andrea E Strahan, Christina Mikosz, Curtis S Florence

Registry-linked trialAbstract read
In one paragraph

Article in Medical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07498491 (A Single-Arm Pilot Study Investigating Weighted Blanket Use for Chronic Pain), which is not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07498491 narecruitingnot on this mapstarted 2026, after this paper: background citation

A Single-Arm Pilot Study Investigating Weighted Blanket Use for Chronic Pain

TypeinterventionalSponsorNational University of Natural MedicineRan2026 to 2026Enrolled44ConditionsChronic Pain, Musculoskeletal Pain, Sleep Disturbance, Pain DisordersArmsWeighted Blanket
3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Review
  8. Dopamine transporter gene (Pain reports · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gery P GuyDivision of Overdose Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Gabrielle F MillerDivision of Injury Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Jaswinder K LeghaDivision of Overdose Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
S Michaela RikardDivision of Overdose Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Andrea E StrahanDivision of Overdose Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Christina MikoszDivision of Overdose Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Curtis S FlorenceDivision of Injury Prevention, Centers for Disease Control and Prevention, Atlanta, GA.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundChronic pain affects more than 1 in 5 adults in the United States. Understanding the economic burden of chronic pain can inform interventions and strategies to improve the quality of life for individuals with chronic pain.

objectiveTo estimate the economic cost of chronic pain in the United States in 2021. RESEARCH

designA cross-sectional analysis estimating the economic costs of chronic pain in 2021. SUBJECTS: In 2021, 6445 (representing 65.8 million) adults with chronic pain were identified using ICD-10-CM codes from the nationally representative Medical Expenditure Panel Survey. MEASURES: Direct medical costs were examined by source of payment and service type. Indirect morbidity costs were estimated from lost productivity from employment disability and missed workdays. We evaluated the economic burden of chronic pain by estimating excess costs among individuals with chronic pain compared with individuals without chronic pain using multivariable regression.

resultsIndividuals with chronic pain had additional total annual medical expenditures of $8068 and additional lost productivity of $2923 per person compared with individuals without chronic pain. In 2021, the economic costs of chronic pain in the United States were estimated to be $722.8 billion, including $530.6 billion in medical care costs and $192.2 billion in lost work productivity.

conclusionsThe economic costs of chronic pain are substantial, resulting in excess health care expenditures and lost productivity costs. These findings highlight the importance of interventions and strategies aimed at providing high-quality, accessible, low-barrier, cost-effective pain care to improve quality of life and reduce disruptions in work among adults with chronic pain.

Indexed as

Chronic PainCost of IllnessHealth Care CostsHealth ExpendituresAdultAgedCross-Sectional StudiesEfficiencyFemaleHumansMaleMiddle AgedQuality of LifeUnited Stateschronic paineconomic burdenhealth care expenditureslost productivity

Identifiers

PMID40730349
PMCPMC13284907

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.