Evidence map›Paper›PMID 40730159›Full record

ArticleCell host & microbe2025

Restoration of the human skin microbiome following immune recovery after hematopoietic stem cell transplantation.

You Che, Jungmin Han, Catriona P Harkins, Peng Hou, Sean Conlan, Clay Deming, Adel Amirkhani, Molly A Bingham, Cassandra J Holmes, Hanna Englander and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Observational
  6. Review
  7. Observational
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

You CheDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
Jungmin HanDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
Catriona P HarkinsDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
Peng HouDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
Sean ConlanTranslational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Clay DemingTranslational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Adel AmirkhaniDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
Molly A BinghamThoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Cassandra J HolmesDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
Hanna EnglanderDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
Zeyang ShenTranslational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
NISC Comparative Sequencing ProgramNIH Intramural Sequencing Center, National Human Genome Research Institute, NIH, Rockville, MD 20892, USA.
Leslie Castelo-SoccioDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
Dimana DimitrovaCenter for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Jennifer A KanakryCenter for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Jenna R E BergersonLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Stefania PittalugaLaboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Chen ZhaoThoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Stefania Dell'OrsoGenomic Technology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
Sung-Yun PaiImmune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Dennis D HicksteinImmune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Steven M HollandLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Isaac BrownellDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
Keisuke NagaoDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA.
Corina E GonzalezImmune Deficiency Cellular Therapy Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Nirali N ShahPediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
Alexandra F FreemanLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Helen C SuLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA; Clinical Genomics Program, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA.
Julia A SegreTranslational and Functional Genomics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Heidi H KongDermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892, USA. Electronic address: konghe@mail.nih.gov.

Funding

Effects of systemic and topical perturbations on human microbesZIABC011558 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KONG, HEIDI · 2014 to 2021
$6.9M
Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis PatientsZIABC010938 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KONG, HEIDI · 2009 to 2021
$5.4M
Studies of human microbes and potential perturbationsZIAAR041219 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2025
$4.3M
Studies of Skin Microflora in Healthy Individuals and Atopic Dermatitis PatientsZIAAR041217 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2023
$1.2M
Investigation of the natural history and pathogenesis of skin diseasesZIAAR041218 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KONG, HEIDI · 2022 to 2025
$745k
Intramural NIH HHS Z99 AR999999Intramural NIH HHS ZIA AR041217Intramural NIH HHS ZIA AR041218Intramural NIH HHS ZIA AR041219Intramural NIH HHS ZIA BC010938Intramural NIH HHS ZIA BC011558
6 · The paper itself

Abstract

The human skin microbiome is intricately intertwined with host immunity. While studies have elucidated microbial influences on immunity, understanding how immune alterations modulate this equilibrium remains limited. We investigated the dual impact of immune deficiency and hematopoietic stem cell transplantation (HSCT) on the skin microbiome in 24 patients with dedicator of cytokinesis 8 (DOCK8) deficiency, a rare inborn error of immunity. Analyzing 590 metagenomic and 534 16S rDNA sequencing samples across eight skin sites, we observed disrupted microbiota pre-HSCT (median eukaryotic viruses 67.6% vs. 0.04% in controls), with extremely diverse human papillomaviruses (HPVs) and polyomaviruses-including oncogenic viruses. Specific bacterial species markedly changed, including decreased Staphylococcus aureus post-HSCT. DNA eukaryotic viruses dramatically decreased (79.7% ± 28.3% to 4.9% ± 8.6%; p < 0.01) 12 months post-HSCT. Recovered microbial communities remained relatively stable through 1-year follow-up with clearance of oncogenic HPV and no convergence with transplant donors. These results highlight the immune system's critical role in restoring microbial balance and skin health.

Indexed as

Hematopoietic Stem Cell TransplantationMicrobiotaSkinAdolescentAdultBacteriaChildChild, PreschoolFemaleHumansMaleMetagenomicsRNA, Ribosomal, 16SSkin MicrobiomeYoung AdultRNA, Ribosomal, 16SDOCK8eczemahematopoietic stem cell transplantationmetagenomemicrobiomepapillomaviruspolyomavirusskin microbiomeviruseswarts

Identifiers

PMID40730159
PMCPMC12313297

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.