ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA.
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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- RNA N4-acetylcytidine modification in health and cancer: molecular mechanisms, cellular plasticity, and therapeutic opportunities.Biomarker research · 2026Review
- Article
- NAT10 inhibition alleviates renal tubular epithelial cell senescence by impeding ac4C acetylation of PAPP-A mRNA in diabetic nephropathy.Cell death & disease · 2026Article
- RNA N4-acetylcytidine modification in human cancers: from molecular function to oncogenic mechanisms.iScience · 2026Review
- The NAT10/acCell communication and signaling : CCS · 2026Review
- NAT10 as a central node in cancer biology: integrating epitranscriptomic regulation, metabolic reprogramming, and immune modulation.Frontiers in immunology · 2026Review
- AI-driven pathology in esophageal cancer: from early screening to precision prognostics.Frontiers in oncology · 2026Review
- Functional roles and mechanisms of NAT10-mediated RNA acFrontiers in cell and developmental biology · 2026Review
- Multi-Omics Reveals Dysregulation of the Endosome-Lysosome-Autophagy Axis and Immune-Inflammatory Imbalance in Elderly Sepsis.Clinical interventions in aging · 2026Article
- NAT10 Increases Lysosomal Acidification to Promote Esophageal Cancer Metastasis via ac4C Acetylation of ATP6V0E1 mRNA.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
24 authors.
Yu-Juan ZhanState Key Laboratory of Respiratory Disease, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Chun-Miao DengState Key Laboratory of Respiratory Disease, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Lin TangState Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, 511400, China.
Shu-Jun LiState Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, 511400, China.
Tao-Yang XuState Key Laboratory of Respiratory Disease, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Xian WeiState Key Laboratory of Respiratory Disease, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Xin-Yi ZhangState Key Laboratory of Respiratory Disease, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Can-Can ZhengState Key Laboratory of Respiratory Disease, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Li DengThe Affiliated Traditional Chinese Medicine Hospital, Sleep Research Institute of Traditional Chinese Medicine, Guangzhou Medical University, Guangzhou, 510000, China.
Cui ShaoThe Affiliated Traditional Chinese Medicine Hospital, Sleep Research Institute of Traditional Chinese Medicine, Guangzhou Medical University, Guangzhou, 510000, China.
Zhong-Min OuyangDepartment of Radiology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Alfred King-Yin LamCancer Molecular Pathology and Griffith Medical School, Griffith University, Gold Coast, Queensland, 4222, Australia.
Rong ZhangDepartment of Endoscopy, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Jun LiuState Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510030, China.
Xing-Yuan ShiDepartment of Radiation Oncology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Zhen-Yu PanDepartment of Radiation Oncology, The Affiliated Huizhou Hospital, Guangzhou Medical University, Huizhou, 516000, China.
Wei DaiDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 999077, China.
Ming-Liang HeDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong, 518057, China.
Simon LawDepartment of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 999077, China.
Xu LiDepartment of Thoracic Surgery, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350000, China.
Xiao-Bing ChenDepartment of Oncology, Henan Engineering Research Center of Precision Therapy of Gastrointestinal Cancer & Zhengzhou Key Laboratory for Precision Therapy of Gastrointestinal Cancer, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, 450000, China.
Cheng ZhouDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Bin LiState Key Laboratory of Respiratory Disease, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510700, China.
Wen-Wen XuState Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences, The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, 511400, China.ORCID https://orcid.org/0000-0003-2756-3498
Funding
Guangdong Esophageal Cancer Institute Science and Technology Program M202221Guangdong Natural Science Research International joint project 2023A0505050165Key Laboratory of Guangdong Higher Education Institutes 2021KSYS009National Natural Science Foundation of China 81773244National Natural Science Foundation of China 82073196National Natural Science Foundation of China 82273141National Natural Science Foundation of China 82273368National Natural Science Foundation of China 82273576Natural Science Foundation of Guangdong Province 2022A1515012447Natural Science Foundation of Henan Province 232300421119The Guangzhou Education Bureau Yangcheng Scholar Research Project 202235385The key disciplines of medicine of Guangzhou 2025-2027The Outstanding Youth Program of Guangdong Natural Science Research 2023B1515020012The Science and Technology Program of Guangzhou 2023A03J0425The Science and Technology Program of Guangzhou 2025A03J3287
Abstract
N-acetyltransferase 10 (NAT10)-catalyzed N4-acetylcytidine (ac4C) modification has been reported to drive tumor metastasis. Lysosomal dysregulation plays an important role in human diseases, but its function in esophageal cancer metastasis is unclear. It remains unknown whether NAT10 regulates lysosomal function, and the underlying mechanism and treatment strategy warrants investigation. Here, a novel role of NAT10 in inducing lysosomal acidification is revealed, and the clinical and biological significance of ATP6V0E1 in tumor metastasis is uncovered. Mechanistically, NAT10 promotes the translation efficiency of ATPase H
Indexed as
AcetyltransferasesEsophageal NeoplasmsLysosomesVacuolar Proton-Translocating ATPasesAcetylationAnimalsCell Line, TumorHumansMiceNeoplasm MetastasisN-Terminal AcetyltransferasesRNA, MessengerAcetyltransferasesNAT10 protein, humanN-Terminal AcetyltransferasesRNA, MessengerVacuolar Proton-Translocating ATPasesac4C modificationesophageal cancer metastasislysosomal acidificationNAT10targeted therapy
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.