Evidence map›Paper›PMID 40729522›Full record

ArticleLiver international : official journal of the International Association for the Study of the Liver2025

The Medical Impact of Hepatitis D Virus Infection in Natives and Immigrants: The Italian Paradigm.

Gian Paolo Caviglia, Eleonora Dileo, Antonella Olivero, Giulio Mengozzi, Alessia Ciancio, Alessandro Loglio, Mauro Viganò, Stefano Fagiuoli, Piero Colombatto, Barbara Coco and 46 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
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Article in Liver international : official journal of the International Association for the Study of the Liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. The Medical Impact of Hepatitis D Virus Infection in Natives and Immigrants: The Italian Paradigm.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors.

Gian Paolo CavigliaDepartment of Medical Sciences, University of Torino, Turin, Italy.ORCID 0000-0002-0529-9481
Eleonora DileoDepartment of Medical Sciences, University of Torino, Turin, Italy.ORCID 0009-0006-4970-7762
Antonella OliveroDepartment of Medical Sciences, University of Torino, Turin, Italy.ORCID 0000-0003-0327-3875
Giulio MengozziDepartment of Medical Sciences, University of Torino, Turin, Italy.ORCID 0000-0003-0431-8369
Alessia CiancioDepartment of Medical Sciences, University of Torino, Turin, Italy.
Alessandro LoglioDivision of Gastroenterology, Hepatology and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy.ORCID 0000-0001-8022-8803
Mauro ViganòDivision of Gastroenterology, Hepatology and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy.
Stefano FagiuoliDivision of Gastroenterology, Hepatology and Transplantation, ASST Papa Giovanni XXIII, Bergamo, Italy.ORCID 0000-0001-8308-0701
Piero ColombattoDepartment of Clinical and Experimental Medicine, Hepatology and Liver Physiopathology Laboratory and Internal Medicine Unit, University of Pisa, Pisa, Italy.
Barbara CocoDepartment of Clinical and Experimental Medicine, Hepatology and Liver Physiopathology Laboratory and Internal Medicine Unit, University of Pisa, Pisa, Italy.
Maurizia Rossana BrunettoDepartment of Clinical and Experimental Medicine, Hepatology and Liver Physiopathology Laboratory and Internal Medicine Unit, University of Pisa, Pisa, Italy.
Debora AngrisaniHepatology Unit, AORN A. Cardarelli, Naples, Italy.
Alfonso Galeota LanzaHepatology Unit, AORN A. Cardarelli, Naples, Italy.
Carlo MagniDivision of Infectious Diseases, ASST-FBF-Sacco, Milan, Italy.
Giuliano RizzardiniDivision of Infectious Diseases, ASST-FBF-Sacco, Milan, Italy.
Vincenzo MessinaInfectious Diseases Unit, AORN Sant'Anna e San Sebastiano, Caserta, Italy.
Michele MilellaClinic of Infectious Diseases, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", Bari, Italy.
Annalisa SaracinoClinic of Infectious Diseases, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", Bari, Italy.
Letizia MarinaroClinica Malattie Infettive UniTo, "Ospedale Amedeo di Savoia", Turin, Italy.ORCID 0000-0002-0896-1469
Giuseppe CaritiClinica Malattie Infettive UniTo, "Ospedale Amedeo di Savoia", Turin, Italy.
Valentina CossigaDepartment of Clinical Medicine and Surgery, Liver and Biliary Diseases Unit, University of Naples "Federico II", Naples, Italy.ORCID 0000-0002-0000-1076
Filomena MoriscoDepartment of Clinical Medicine and Surgery, Liver and Biliary Diseases Unit, University of Naples "Federico II", Naples, Italy.
Silvia CretellaInfectious Diseases Unit, Department for Integrated Infectious Risk Management, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.ORCID 0009-0000-1249-1618
Gabriella VerucchiInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Elisa BiliottiInfectious Diseases and Hepatology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Giampiero D'OffiziInfectious Diseases and Hepatology Unit, National Institute for Infectious Diseases Lazzaro Spallanzani IRCCS, Rome, Italy.
Marcello FeasiDepartment of Infectious Diseases, Galliera Hospital, Genoa, Italy.
Emanuele PontaliDepartment of Infectious Diseases, Galliera Hospital, Genoa, Italy.
Carmine CoppolaUnit of Hepatology and Interventional Ultrasonography, Department of Internal Medicine, OORR Area Stabiese, Gragnano, Italy.
Rachele RapettiDepartment of Translational Medicine (DiMeT), Internal Medicine, Azienda Ospedaliero-Universitaria "Maggiore Della Carità", Università del Piemonte Orientale, Novara, Italy.
Mario PirisiDepartment of Translational Medicine (DiMeT), Internal Medicine, Azienda Ospedaliero-Universitaria "Maggiore Della Carità", Università del Piemonte Orientale, Novara, Italy.
Antonio IzziUOC di Malattie Infettive Emergenti e Ad Alta Contagiosità, Ospedale Cotugno, Naples, Italy.ORCID 0000-0001-6776-5655
Teresa SantantonioInfectious Diseases Unit, Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
Vito Di MarcoSection of Gastroenterology and Hepatology, Dipartimento Di Promozione Della Salute, Materno Infantile, Medicina Interna e Specialistica Di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.
Aldo MarroneDepartment of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.
Nicola CoppolaInfectious Diseases Unit, Department of Mental Health and Public Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID 0000-0001-5897-4949
Marco RizziSC Infectious Diseases, ASST Papa Giovanni XXIII, Bergamo, Italy.ORCID 0000-0002-2081-8542
Anna Maria CattelanInfectious and Tropical Diseases Unit, Padua University Hospital, Padua, Italy.
Grazia Anna NiroGastroenterology Unit, Fondazione Casa Sollievo Della Sofferenza IRCCS, San Giovanni Rotondo, Italy.
Pierluigi ToniuttoHepatology and Liver Transplant Unit, Azienda Sanitaria Universitaria Integrata di Udine, Udine, Italy.ORCID 0000-0002-2566-3041
Francesca Romana PonzianiLiver Unit, Centro Malattie Dell'apparato Digerente (CEMAD), Medicina Interna e Gastroenterologia, Fondazione Policlinico Universitario Gemelli IRCCS, Rome, Italy.ORCID 0000-0002-5924-6238
Luca Saverio BelliHepatology and Gastroenterology Unit, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.ORCID 0000-0001-8714-2439
Alessandro FedericoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID 0000-0002-0885-0793
Gaetano BertinoDepartment of Clinical and Experimental Medicine, Hepatology Unit, University Hospital Policlinico "G. Rodolico - San Marco", University of Catania, Catania, Italy.ORCID 0000-0002-4557-2649
Michele BaroneGastroenterology Unit, Department of Precision and Regenerative Medicine-Jonian Area-(DiMePRe-J), University of Bari "Aldo Moro", Policlinic University Hospital, Bari, Italy.ORCID 0000-0001-8284-5127
Massimo PuotiDivision of Infectious Diseases, Department of Medicine, ASST Grande Ospedale Metropilitano Niguarda, University of Milan Bicocca, Milan, Italy.ORCID 0000-0003-3278-7138
Alberto CivolaniTeaching Hospital "Duilio Casula", Azienda Ospedaliero-Universitaria di Cagliari, Cagliari, Italy.
Marco DistefanoUOSD Hepatology, Ospedale Umberto I°, ASP 8 Siracusa, Siracusa, Italy.
Lorenzo Antonio SuraceDipartimento Di Prevenzione, Azienda Sanitaria Provinciale di Catanzaro, Centro di Medicina del Viaggiatore e Delle Migrazioni, Lamezia Terme, Italy.ORCID 0009-0004-1004-4573
Raffaele CozzolongoGastroenterology Unit, IRCCS "S. De Bellis", Castellana Grotte, Italy.ORCID 0000-0002-8343-5864
Ester Marina CelaGastroenterology Unit, Riuniti Polyclinic of Foggia, Foggia, Italy.
Elisabetta TetiInfectious Disease Unit, Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Pietro LamperticoDivision of Gastroenterology and Hepatology, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-1026-7476
Tommaso StroffoliniDepartment of Tropical and Infectious Diseases, Policlinico Umberto I, Rome, Italy.
Mario RizzettoDepartment of Medical Sciences, University of Torino, Turin, Italy.
HDV Describe Study Group

Funding

Gilead Sciences IN-IT-980-6382
6 · The paper itself

Abstract

BACKGROUND AND

aimOngoing migratory flows are reconstituting the hepatitis D virus (HDV) reservoir in Italy. We aimed to characterise the current clinical and virologic features of HDV infection in both native Italians and migrants.

methodsWe enrolled 515 hepatitis B surface antigen (HBsAg)-positive patients with detectable anti-HDV antibodies from 32 Italian centres between August 2022 and July 2024; all patients underwent centralised virologic assessment.

resultsOverall, 432 out of 515 (83.9%) patients were HDV-RNA-positive (4.39, 1.30-5.82 Log IU/mL; 99.0% HDV genotype-1). HDV-RNA levels correlated with ALT (r

conclusionsThe current clinical landscape of chronic HDV infections in Italy is heterogeneous, changing the perspective of CHD as uniformly severe; although cirrhosis remains common, a substantial proportion of both native Italians and migrants present with milder forms of disease.

Indexed as

Emigrants and ImmigrantsHepatitis DHepatitis D, ChronicHepatitis Delta VirusAdultAgedCarcinoma, HepatocellularFemaleHepatitis AntibodiesHepatitis B Surface AntigensHumansItalyLiver CirrhosisLiver NeoplasmsMaleMiddle AgedHepatitis AntibodiesHepatitis B Surface AntigensRNA, Viralchronic hepatitis DcirrhosisepidemiologyHDVHDV‐RNA

Identifiers

PMID40729522
PMCPMC12306849

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.