ArticleEuropean journal of neurology2025
Small Fiber Morphology and Function in Inclusion Body Myositis-A Multimodal Assessment Including Confocal Corneal Microscopy.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Lower-Limb Motor Function, Mobility, Balance, Falls and Intervention Effects in Inclusion Body Myositis: A Systematic Review.Journal of clinical medicine · 2026Review
- Reply to Owais Et al. Concerns Regarding "Small Fiber Morphology and Function in Inclusion Body Myositis-A Multimodal Assessment Including Confocal Corneal Microscopy".European journal of neurology · 2025Article
- Concerns Regarding "Small Fiber Morphology and Function in Inclusion Body Myositis-A Multimodal Assessment Including Confocal Corneal Microscopy".European journal of neurology · 2025Article
- Small Fiber Morphology and Function in Inclusion Body Myositis-A Multimodal Assessment Including Confocal Corneal Microscopy.European journal of neurology · 2025Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe extent of peripheral nerve involvement in inclusion body myositis (IBM) remains a topic of ongoing scientific discussion. In this study, we aimed to explore the involvement of small nerve fibers in IBM using a range of diagnostic methods, including, for the first time, corneal confocal microscopy (CCM).
methodsNineteen clinic-pathologically or clinically defined IBM patients underwent comprehensive clinical and electrophysiological examinations. A multimodal small fiber examination was performed, including a skin biopsy of the thigh and lower leg, quantitative sensory testing of the feet, and CCM. Pain levels and quality of life were also assessed using standardized questionnaires (Small Fiber Neuropathy Screening List, PainDETECT, Brief Pain Inventory, Short Form-36).
resultsThe motor and sensory neurography identified large fiber neuropathy in 67% of cases. Regarding small fibers evaluation, skin biopsy revealed pathological findings in 72% of cases and CCM in 32% of cases. Quantitative sensory testing results predominantly indicated large fiber damage (61%), with small fiber pathology identified in only 12% of cases. Questionnaire responses suggested a slight pain-related impact on patients' quality of life. DISCUSSION: Small nerve fiber pathology is a frequent finding in skin biopsies of IBM patients. However, noninvasive methods like CCM appear less sensitive than skin biopsy for diagnosing small fiber pathology in IBM patients. Further studies are needed to refine diagnostic approaches and better understand the role of small fiber involvement in IBM.
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