Evidence map›Paper›PMID 40729389›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Qi He, Jiawei Lu, Qiushi Liang, Lutian Yao, Tingfang Sun, Huan Wang, Michael Duffy, Xi Jiang, Yuewei Lin, Ji-Hyung Lee and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. A who's who of cell types in skeletal muscle.Communications biology · 2026
    Review
  2. Review
  3. Clec3bBone research · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Stage-resolved geography of mouse skeletal stem cells.Journal of bone and mineral metabolism · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Qi He *Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0003-2753-2536
Jiawei Lu *Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-7606-0080
Qiushi LiangDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Lutian YaoDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Tingfang SunDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-4290-0432
Huan WangDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0001-5426-3971
Michael DuffyDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0001-5325-3683
Xi JiangDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Yuewei LinDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Ji-Hyung LeeDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Jaimo AhnDepartment of Orthopaedics, Grady Memorial Hospital, Emory University, Atlanta, GA 30303.ORCID 0000-0001-8151-9987
Nathaniel A DymentDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Foteini MourkiotiDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-7119-6640
Joel D BoerckelDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0003-3126-3025
Ling QinDepartment of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0002-2582-0078

Funding

Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
Control of bone physiology by a novel type of adipose cellsR01AG069401 · NIA · UNIVERSITY OF PENNSYLVANIA · PI QIN, LING · 2021 to 2025
$2.3M
HHS | NIH | National Institute on Aging (NIA) NIA R01AG069401NIAMS NIH HHS P30 AR069619NIA NIH HHS R01 AG069401Penn | Penn Med | Penn Center for Musculoskeletal Disorders (PCMD) P30AR069619
6 · The paper itself

Abstract

Clinically, compromised fracture healing often occurs at sites with less muscle coverage and muscle flaps can provide the necessary healing environment for appropriate healing in severe bone loss. However, the underlying mechanisms are largely unknown. Here, we established a mouse reporter model for studying muscle cell contribution to bone fracture repair. Analyzing skeletal muscle scRNA-seq datasets revealed that

Indexed as

Fracture HealingFractures, BoneMuscle, SkeletalStem CellsAnimalsMaleMesenchymal Stem CellsMiceOsteoblastsOsteocytesPeriosteumFAPsfracture healingmesenchymal progenitorsmuscleperiosteum

Identifiers

PMID40729389
PMCPMC12337308

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.