Evidence map›Paper›PMID 40729383›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Deficiency in transmitter release triggers homeostatic transcriptional changes that increase presynaptic excitability.

Caroline A Cypranowska, Maya Feldthouse, Yoon Gi Choi, Dariya Bakshinska, Rachel Li, Zachary L Newman, Ehud Y Isacoff

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Behavioral resilience via dynamic circuit firing homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Synapse-specific catecholaminergic modulation of neuronal glutamate release.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Caroline A CypranowskaDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.
Maya FeldthouseHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720.
Yoon Gi ChoiFunctional Genomics Laboratory, University of California Berkeley, Berkeley, CA 94720.
Dariya BakshinskaHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA 94720.
Rachel LiDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.
Zachary L NewmanDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.
Ehud Y IsacoffDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720.ORCID 0000-0003-4775-9359

Funding

Synaptic to circuit homeostasis in the Drosophila locomotor systemR01NS107506 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2019 to 2023
$1.6M
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS107506NINDS NIH HHS R01 NS107506NSF | NSF Graduate Research Fellowship Program (GRFP) 1106400
6 · The paper itself

Abstract

Weakening of synaptic transmission at the

Indexed as

HomeostasisMotor NeuronsNeurotransmitter AgentsPresynaptic TerminalsSynaptic TransmissionTranscription, GeneticAction PotentialsAnimalsDrosophilaDrosophila melanogasterDrosophila ProteinsGlutamic AcidLarvaNeuromuscular JunctionDrosophila ProteinsGlutamic AcidNeurotransmitter Agentsexcitabilityhomeostasispotassium channelRNA-seqsynapse

Identifiers

PMID40729383
PMCPMC12337328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.