Evidence map›Paper›PMID 40729382›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

A granulin-positive macrophage subtype in mycobacterial granulomas alleviates tissue damage by limiting excessive inflammation.

Geyang Luo, Yanling Wen, Min Wang, Hao Wang, Duoduo Li, Mingfeng Liao, Dong Zeng, Sizhu Luo, Liangfei Niu, Tao Sun and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Macrophage-Derived Extracellular Vesicles Deliver Progranulin to Alleviate Skin Wound Fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Geyang Luo *Center for Tuberculosis Research, Shanghai Public Health Clinical Center, Key Laboratory of Medical Molecular Virology of the Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, China.
Yanling Wen *Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518100, China.
Min Wang *Center for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Hao WangCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Duoduo LiDepartment of Pathology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Mingfeng LiaoInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518100, China.
Dong ZengDepartment of Pathology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Sizhu LuoCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Liangfei NiuCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Tao SunCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Peng SunCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Liyi QinNational Tuberculosis Clinical Lab, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Weimin LiNational Tuberculosis Clinical Lab, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China.
Shu SongDepartment of Pathology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Howard E TakiffInstituto Venezolano de Investigaciones Científicas, Centro de Microbiología y Biología Celular, Caracas 1020A, Venezuela.
Shuye ZhangClinical Center for BioTherapy, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Qian GaoCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Key Laboratory of Medical Molecular Virology of the Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, China.ORCID 0000-0002-8489-3672
Zheng ZhangInstitute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen 518100, China.ORCID 0000-0002-3544-1389
Bo YanCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Key Laboratory of Medical Molecular Virology of the Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 201508, China.ORCID 0000-0002-7308-8942

Funding

MOST | National Key Research and Development Program of China (NKPs) 2023YFE0199200MOST | National Natural Science Foundation of China (NSFC) 82272376MOST | National Natural Science Foundation of China (NSFC) 82372263MOST | NSFC | National Science Fund for Distinguished Young Scholars (NSF for Distinguished Young Scholars) 82025022the Shanghai "Science and Technology Innovation Action Plan" Medical Innovation Research Special Project 22Y11920500the Shenzhen Clinical Research Center for Tuberculosis 20210617141509001the Shenzhen Science and Technology Program ZDSYS20210623091810030
6 · The paper itself

Abstract

Granulomas play a crucial role in the pathology of tuberculosis, but the immune environment governing their formation remains largely unknown. To explore the dynamic changes in the immune microenvironment during the formation of tuberculous granulomas, we infected adult zebrafish with

Indexed as

GranulomaInflammationMacrophagesMycobacterium Infections, NontuberculousMycobacterium marinumProgranulinsAnimalsKidneyZebrafishProgranulinsgranulingranulomaimmune microenvironmentmacrophageMycobacterium

Identifiers

PMID40729382
PMCPMC12337285

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.