Evidence map›Paper›PMID 40729249›Full record

ArticleThe Gerontologist2025

Does caregiver stress get under the skin? Associations with care recipient inflammation.

Sophia Tsuker, Yin Liu, Lauren Bangerter, Elaina Baker, Hannah Lee, Amanda Leggett

Abstract read
In one paragraph

Article in The Gerontologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sophia TsukerInstitute of Gerontology, Wayne State University, Detroit, Michigan, United States.ORCID 0009-0005-4757-9827
Yin LiuHuman Development and Family Studies, Utah State University, Logan, Utah, United States.
Lauren BangerterMedstar Health, Washington, District of Columbia, United States.ORCID 0000-0001-8452-2495
Elaina BakerSchool of Medicine, University of Michigan, Ann Arbor, Michigan, United States.
Hannah LeeSchool of Medicine, Wayne State University, Detroit, Michigan, United States.
Amanda LeggettInstitute of Gerontology, Wayne State University, Detroit, Michigan, United States.ORCID 0000-0001-7895-3862

Funding

Michigan Alzheimer's Disease Core CenterP30AG053760 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIEBERMAN, ANDREW P · 2016 to 2020
$10.1M
NIA NIH HHS NIA R01AG079097; NIAP30AB072931NIA NIH HHS P30 AG053760NIA NIH HHS U01AG032947, R01AG054004
6 · The paper itself

Abstract

BACKGROUND AND

objectivesA wealth of research has focused on the caregiving stress process, while less is devoted to understanding how caregiver stress may impact health outcomes in the care recipient. We examine whether higher levels of caregiver role overload will be associated with care recipients' C-reactive protein (CRP) concentrations, an inflammatory biohormone. Additionally, this study observed whether caregivers' positive and negative appraisals of caregiving moderated this association. RESEARCH DESIGN AND

methodsData are drawn from the 2017 National Health and Aging Trends Study (NHATS) and associated National Study of Caregiving (NSOC). CRP levels were assessed via dried blood spot sample. We examine the main effect of caregiver role overload on care recipient CRP, adjusting for care recipient demographics and care context. Separate models were run on the interaction of overload with emotional difficulty of care and caregiving gains to test whether appraisal of care moderates the association between caregiving overload and care recipient CRP.

resultsCare recipients were predominantly female (63.72%) and averaged 78.32 years old. Caregiving role overload was positively associated with care recipient CRP concentrations (B = 0.06, β = 0.08, SE = 0.25, p = .02). No significant interaction was observed between caregiving gains or caregiving emotional difficulty in predicting CRP. DISCUSSION AND IMPLICATIONS: Care recipients demonstrated greater CRP concentrations when their caregiver reported higher role overload, regardless of their appraisal of the care context. Efforts to help caregivers delegate tasks or offer respite may reduce overload and have positive impact on care recipients' physiological health.

Indexed as

CaregiversC-Reactive ProteinInflammationStress, PsychologicalAgedAged, 80 and overFemaleHumansMaleMiddle AgedC-Reactive ProteinAppraisalCaregiver overloadCaregiversC-reactive protein

Identifiers

PMID40729249
PMCPMC12470654

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.