Improvement in Intestinal-Failure-Associated Liver Disease by Using Parenteral Fish Oil as Monotherapy: Case-Based Review of the Literature.

Smaragdi Fessatou, Afroditi Kourti, Nikolaos Zavras, Sofia Zouganeli, Niki Kouna, Eustathios Stefos, Ino Kanavaki

Abstract readCase Reports

In one paragraph

Article in Reports (MDPI), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Smaragdi FessatouDepartment of Paediatric Gastroenterology, Hepatology and Nutrition, 3rd Department of Paediatrics, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Afroditi KourtiDepartment of Paediatric Gastroenterology, Hepatology and Nutrition, 3rd Department of Paediatrics, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0003-0177-5193

Nikolaos ZavrasDepartment of Pediatric Surgery, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.ORCID 0000-0003-2546-4533

Sofia ZouganeliDepartment of Nutrition and Dietetics, Attikon University General Hospital, 12462 Athens, Greece.ORCID 0000-0001-6298-7320

Niki KounaSecond Department of Anesthesiology, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Eustathios StefosDepartment of Paediatric Gastroenterology, Hepatology and Nutrition, 3rd Department of Paediatrics, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Ino KanavakiDepartment of Paediatric Gastroenterology, Hepatology and Nutrition, 3rd Department of Paediatrics, Attikon University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal-failure-associated liver disease (IFALD) is a common complication of prolonged parenteral nutrition (PN). Risk factors for IFALD include clinical features, as well as medical interventions, and its management was initially based on the decrease or interruption of parenteral nutrition while increasing enteral nutrition. However, the tolerance of full enteral nutrition in children with intestinal failure may require prolonged intestinal rehabilitation over a period of years. As a consequence, infants unable to wean from PN are prone to develop end-stage liver disease. We describe the case of an infant receiving long-term PN who was diagnosed with IFALD wherein we were able to reverse IFALD by switching lipid emulsions to fish oil monotherapy. A systemic review of case reports and case series on reversing IFALD using fish oil lipid emulsion follows the case description.

Indexed as

fish oilintestinal-failure-associated liver diseaseintravenous lipid emulsionparenteral nutrition

Identifiers

PMID40729195

DOI10.3390/reports6020028

PMCPMC12225342

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.