Evidence map›Paper›PMID 40729101›Full record

ArticleThe journal of physical chemistry. B2025

Pathogenic

Ayan Bhattacharjee, Gregory R Bowman

Abstract read
In one paragraph

Article in The journal of physical chemistry. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Ayan BhattacharjeeDepartments of Biochemistry & Biophysics and Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0001-7665-5554
Gregory R BowmanDepartments of Biochemistry & Biophysics and Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-2083-4892

Funding

Understanding and controlling protein energy landscapes by combining simulations and experimentsR35GM152085 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Gregory Bowman · 2024 to 2026
$1.2M
NIGMS NIH HHS R35 GM152085
6 · The paper itself

Abstract

Mechanistic insight into biophysical perturbations caused by pathogenic missense mutations is highly valuable information for the rational design of therapeutics. For hereditary breast and ovarian cancers, multiple pathogenic mutations in the N-terminal domain of

Indexed as

BRCA1 ProteinTumor Suppressor ProteinsUbiquitin-Protein LigasesAllosteric RegulationHumansMolecular Dynamics SimulationMutationBARD1 protein, humanBRCA1 ProteinBRCA1 protein, humanTumor Suppressor ProteinsUbiquitin-Protein Ligases

Identifiers

PMID40729101
PMCPMC12362357

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.