Evidence map›Paper›PMID 40729054›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2025

Potential of Corncob Extract on the Expression of Ki-67 and Caspase3 in Breast Cancer.

Fahria Fahria, Theresia Indah Budhy, Jusak Nugraha, Desak Gede Agung Suprabawati, Hani Plumeriastuti, Retno Pallupi

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Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Fahria FahriaMaster of Immunology Study Program, Postgraduate School, University Airlangga, Surabaya, Indonesia.
Theresia Indah BudhyDepartment of Oral and Maxilofacial Pathology, Faculty of Dental Medicine, University Airlangga, Indonesia.ORCID 0000-0002-5068-4493
Jusak NugrahaDepartment of Clinical Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo Hospital, Indonesia.
Desak Gede Agung SuprabawatiDepartment of Surgery, Faculty of Medicine, University Airlangga, Surabaya, Indonesia.
Hani PlumeriastutiDepartment of Pathobiology, Faculty veterinary medicine, University Airlangga, Surabaya, Indonesia.
Retno PallupiDepartment of Oral Biology, Faculty of Dental Medicine, University Airlangga, Surabaya, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe expression parameters of ki-67 and caspase3 in breast cancer model rats will be examined in this study to evaluate the effect of corncob extract administration on breast tissue of breast cancer animal model.

methodsTwenty-one female Sprague Dawley rats were induced by DMBA. The experimental group was divided into three groups, after the formation of breast cancer experimental animals, the treatment group was given corncob, and the group of rats that were given 200 mg/kg BW of corncob extract and 250 mg/kg BW. The expression of ki-67 and caspase3 was evaluated using the immunohistochemical method.

resultsCorncob extract increased Caspase-3 expression in breast cancer experimental animals but did not significantly reduce Ki-67 expression in breast cancer in Spraque Dawley rats.

conclusionAdministration of corncob extract had an effect on caspase3 expression (as a marker of apoptosis) but had no effect on the expression of ki-67 (as a marker of proliferation.

Indexed as

Breast NeoplasmsCaspase 3Ki-67 AntigenMammary Neoplasms, ExperimentalPlant Extracts9,10-Dimethyl-1,2-benzanthraceneAnimalsApoptosisBiomarkers, TumorCell ProliferationFemaleRatsRats, Sprague-Dawley9,10-Dimethyl-1,2-benzanthraceneBiomarkers, TumorCaspase 3Ki-67 AntigenPlant Extractsbreast cancerCaspase3CorncobKi67

Identifiers

PMID40729054
PMCPMC12507061

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.