SynthesisAsian Pacific journal of cancer prevention : APJCP2025
The Prognostic Role of Tumor-Stroma Ratio in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.
Synthesis in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe tumor-stroma ratio (TSR) has emerged as a potential prognostic marker in several cancers, including oral squamous cell carcinoma (OSCC). However, results with high certainty of evidence are required for its implementation in routine histological analysis. Therefore, this systematic review aims to summarize the evidence on the prognostic role of the TSR in OSCC.
methodsA search was performed in Embase, PubMed, Scopus, Livivo, Web of Science, and Google Scholar. We included cohort studies that evaluated the association between TSR and survival. Reviews and studies that did not report hazard ratio (HR) were excluded.
resultsThis systematic review included 10 studies and showed an association between TSR and survival. Low TSR (stroma-rich) was associated with decreased overall survival (OS) in univariate analysis (HR = 3.00, 95% CI: 1.69-5.30, p<0.01) and multivariate analysis (HR = 2.91, 95% CI: 2.19-3.87, p<0.01); poorer disease-specific survival (DSS) in univariate analysis (HR = 2.57, 95% CI: 1.95-3.39, p<0.01) and multivariate analysis (HR = 2.64, 95% CI: 1.83-3.79, p<0.01); and poorer disease-free survival (DFS) in univariate (HR = 2.56, 95% CI: 2.02-3.23, p<0.01) and multivariate analyses (HR = 2.11, 95% CI: 1.74-2.56, p<0.01).
conclusionOur findings indicate that TSR is an independent prognostic factor for OS, DSS, and DFS in oral squamous cell carcinoma. However, future studies are needed to assess the prognostic role of this histopathological parameter in OSCC to increase the certainty of the evidence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.