Evidence map›Paper›PMID 40729016›Full record

ReviewCurrent issues in molecular biology2025

The Clock and the Brain: Circadian Rhythm and Alzheimer's Disease.

Samaneh Ghorbani Shirkouhi, Ashkan Karimi, Seyed Sepehr Khatami, Ashkan Asgari Gashtrodkhani, Farzin Kamari, Morten Blaabjerg, Sasan Andalib

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Samaneh Ghorbani ShirkouhiStudent Research Committee, School of Medicine, Shahroud University of Medical Sciences, Shahroud 36147-73943, Iran.
Ashkan KarimiDepartment of Psychology, Centre for Vision Research, York University, Toronto, ON M3J 1P3, Canada.ORCID 0009-0002-5017-1978
Seyed Sepehr KhatamiDepartment of Neurology, University of California Irvine, Irvine, CA 92617, USA.ORCID 0000-0002-2164-4564
Ashkan Asgari GashtrodkhaniSchool of Medicine, Guilan University of Medical Sciences, Rasht 41937-13111, Iran.ORCID 0009-0001-4163-2405
Farzin KamariDepartment of Neurophysiology, Institute of Physiology, Eberhard Karls University of Tuebingen, 72074 Tuebingen, Germany.ORCID 0000-0003-4774-5168
Morten BlaabjergResearch Unit of Neurology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense, Denmark.ORCID 0000-0001-6007-1861
Sasan AndalibResearch Unit of Neurology, Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's Disease (AD) is the most common type of dementia. The circadian system, which is controlled by the master clock in the Suprachiasmatic Nucleus (SCN) of the hypothalamus, is crucial for various physiological processes. Studies have shown that changes in the circadian rhythms can deteriorate neurodegenerative diseases. Changes in the SCN are associated with cognitive decline in AD. The cognitive impairments in AD, especially memory dysfunctions, may be related to Circadian Rhythm Disturbances (CRDs). Moreover, rhythmic expression of clock genes is disrupted in AD patients. There is a circadian pattern of inflammatory processes in AD, and dysregulation of core clock genes promotes neuroinflammation. The present narrative review addresses the intricate link between CRDs and AD, revisiting the relevant cellular and molecular mechanisms. The association between CRDs and AD highlights the need for further investigation of the underlying mechanisms.

Indexed as

Alzheimer’s Diseasecellular mechanismscircadian rhythmmolecular mechanisms

Identifiers

PMID40729016
PMCPMC12294067

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.