Evidence map›Paper›PMID 40728898›Full record

ArticleThe Journal of clinical investigation2025

Elesclomol-copper therapy improves neurodevelopment in two children with Menkes disease.

Elena Godoy-Molina, Natalia L Serrano, Aquilina Jiménez-González, Miquel Villaronga, Rosa M Marqués Pérez-Bryan, Rubén Varela-Fernández, Stephanie Lotz-Esquivel, Alba Hevia Tuñón, Prachi P Trivedi, Nina Horn and 22 more

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Feeding-Triggered Seizures in a Newborn withJournal of clinical medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Elena Godoy-MolinaComplex Chronic Children and Palliative Care Unit, Department of Pediatrics, Hospital Regional Universitario, Málaga, Spain.
Natalia L SerranoLaboratory of Neurogenetics and Molecular Medicine, Center for Genomic Sciences in Medicine, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
Aquilina Jiménez-GonzálezDepartment of Pediatrics, Complejo Asistencial Universitario de León, León, Spain.
Miquel VillarongaDepartment of Pharmacy, Hospital Sant Joan de Déu, Barcelona, Spain.
Rosa M Marqués Pérez-BryanCentro de Atención Temprana Dr. Miguel de Linares Pezzi, Dulce Nombre de Maria Psychopedagogic Institute, Málaga, Spain.
Rubén Varela-FernándezDepartment of Pharmacy, Complejo Asistencial Universitario de León, León, Spain.
Stephanie Lotz-EsquivelLaboratory of Neurogenetics and Molecular Medicine, Center for Genomic Sciences in Medicine, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
Alba Hevia TuñónDepartment of Pediatrics, Complejo Asistencial Universitario de León, León, Spain.
Prachi P TrivediDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, Texas, USA.
Nina HornDepartment of Genetics, Kennedy Centre and Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Joseph F StandingInstitute for Child Health, University College London, London, United Kingdom.
Víctor Mangas-SanjuanDepartment of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, Valencia, Spain.
Mercè CapdevilaDepartment of Chemistry, Faculty of Sciences, Universitat Autònoma de Barcelona, Cerdanyola de Vallès, Barcelona, Spain.
Aurora MateosMenkes International Association, Málaga, Spain.
Denis BrounMenkes International Association, Málaga, Spain.
Svetlana LutsenkoDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ines Medina-RiveraNeuropsychology Unit, Department of Pediatric Neurology, and.
Rafael ArtuchDepartment of Clinical Biochemistry, Hospital Sant Joan de Déu, Barcelona, Spain.
Cristina JouDepartment of Pathology.
Mònica RoldánConfocal Microscopy and Cellular Imaging Unit and.
Pedro Arango-SanchoDepartment of Pediatric Nephrology, Hospital Sant Joan de Déu, Barcelona, Spain.
Mónica Saez-VillafañeDepartment of Pharmacy, Complejo Asistencial Universitario de León, León, Spain.
Juan J Ortiz-de-UrbinaDepartment of Pharmacy, Complejo Asistencial Universitario de León, León, Spain.
Angela Pieras-LópezDepartment of Pharmacy, Hospital Sant Joan de Déu, Barcelona, Spain.
Marta DueroDepartment of Pharmacy, Hospital Sant Joan de Déu, Barcelona, Spain.
Rosa FarréDepartment of Pharmacy, Hospital Sant Joan de Déu, Barcelona, Spain.
Jordi PijuanLaboratory of Neurogenetics and Molecular Medicine, Center for Genomic Sciences in Medicine, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
Janet HoenickaLaboratory of Neurogenetics and Molecular Medicine, Center for Genomic Sciences in Medicine, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
James C SacchettiniDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, Texas, USA.
Michael J PetrisDepartments of Ophthalmology and Biochemistry, University of Missouri, Columbia, Missouri, USA.
Vishal M GohilDepartment of Biochemistry & Biophysics, Texas A&M University, College Station, Texas, USA.
Francesc PalauLaboratory of Neurogenetics and Molecular Medicine, Center for Genomic Sciences in Medicine, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.

Funding

Novel roles of copper in adaptive responses to hypoxiaR01DK131190 · NIDDK · UNIVERSITY OF MISSOURI-COLUMBIA · PI PETRIS, MICHAEL J. · 2021 to 2025
$2.1M
Mitochondrial Copper BiologyR35GM152102 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI Vishal Mahendrasingh Gohil · 2024 to 2026
$1.7M
Mechanisms of elesclomol-mediated copper delivery to cuproenzymes in cellsR01GM143630 · NIGMS · TEXAS A&M AGRILIFE RESEARCH · PI GOHIL, VISHAL MAHENDRASINGH · 2021 to 2023
$979k
NIDDK NIH HHS R01 DK131190NIGMS NIH HHS R01 GM143630NIGMS NIH HHS R35 GM152102
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Clinical ResearchGenetic diseasesGeneticsNeurodegenerationNeuroscienceTherapeutics

Identifiers

PMID40728898
PMCPMC12483558

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.