Evidence map›Paper›PMID 40728872›Full record

ArticleACS sensors2025

An Enhanced Red Bioluminescent Indicator for Responsive Detection of Physiological Calcium Dynamics in Cells and Mice.

Xiaodong Tian, Yiyu Zhang, Haoyang Du, Wenyuan Huang, Laurie Anne Bizimana, Nozomi Nishimura, Hui-Wang Ai

Abstract read
In one paragraph

Article in ACS sensors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xiaodong TianDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.ORCID 0000-0001-9590-9943
Yiyu ZhangDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.ORCID 0000-0001-8636-2827
Haoyang DuMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14853, United States.ORCID 0009-0008-7107-0651
Wenyuan HuangDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.
Laurie Anne BizimanaMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14853, United States.
Nozomi NishimuraMeinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14853, United States.
Hui-Wang AiDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.ORCID 0000-0002-5664-3270

Funding

Next-Gen Fluorescent Indicators for Imaging Synaptic Zinc in Cortical Sound ProcessingR01EB033172 · NIBIB · UNIVERSITY OF VIRGINIA · PI Huiwang Ai, Thanos Tzounopoulos · 2022 to 2026
$3.3M
Next-Generation ATP-Independent Luciferases, Luciferins, and Bioluminescent Calcium IndicatorsR01EB035430 · NIBIB · UNIVERSITY OF VIRGINIA · PI Huiwang Ai · 2024 to 2026
$1.4M
Fluorescent Redox Indicators to Image Oxidative Stress in Alzheimer's DiseaseR01AG077773 · NIA · UNIVERSITY OF VIRGINIA · PI Huiwang Ai · 2025 to 2026
$1.0M
Simultaneous, Cell-Resolved, Bioluminescent Recording From MicrocircuitsR21EY033085 · NEI · CORNELL UNIVERSITY · PI NISHIMURA, NOZOMI, SCHAFFER, CHRIS B · 2021 to 2022
$492k
Disease-homing light delivery by engineering bioluminescent immune cells for whole body precision photomedicineR21CA263452 · NCI · NORTHEASTERN UNIVERSITY · PI SPRING, BRYAN QUILTY · 2023 to 2024
$414k
NCI NIH HHS R21 CA263452NEI NIH HHS R21 EY033085NIA NIH HHS R01 AG077773NIBIB NIH HHS R01 EB033172NIBIB NIH HHS R01 EB035430
6 · The paper itself

Abstract

Calcium (Ca

Indexed as

CalciumLuminescent AgentsLuminescent MeasurementsAnimalsBrainHumansMiceMice, Inbred C57BLNeuronsCalciumLuminescent Agentsbioluminescence imagingbioluminescent sensorcalcium imagingprotein engineeringred-shifted emission

Identifiers

PMID40728872
PMCPMC12351538

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.