ArticleGastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates
Correlation of Fecal, Plasma, Serum, and Salivary Calprotectin to Endoscopic and Histologic Outcomes in Patients With Crohn's Disease: A Pilot Study.
Article in Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Noninvasive salivary biomarkers (PTX3, calprotectin, and IL-8) for early-onset neonatal pneumonia: case-control differences and exploratory discrimination.Frontiers in pediatrics · 2026Article
- Analytical validation of an automated assay to measure calprotectin (S100A8/A9) in dog saliva and serum and changes in canine leishmaniasis, pyometra and hyperadrenocorticism.BMC veterinary research · 2025Article
- Measurement of Calprotectin (S100A8/A9) in the Saliva of Pigs: Validation Data of A Commercially Available Automated Assay and Changes in Sepsis, Inflammation, and Stress.Animals : an open access journal from MDPI · 2023Article
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Authors and funding
8 authors.
Funding
Abstract
Easily obtained, noninvasive biomarkers are needed for Crohn's disease monitoring. This pilot study compared associations between calprotectin levels in stool, saliva, and blood to assess their correlation with endoscopic and histologic outcomes among patients with Crohn's disease. Participants recruited from an Inflammatory Bowel Disease center provided stool, blood, and saliva samples prior to undergoing scheduled colonoscopy (n = 17). We collected participant demographics and clinical disease activity. Endoscopic disease was assessed with the Simple Endoscopic Score. Histologic disease was assessed with the Robarts Histological Index. The mean age of the sample was 32.3 (SD 7.5) years. Correlations with endoscopic disease activity were 0.83 for fecal calprotectin, 0.26 for plasma calprotectin, 0.24 for serum calprotectin, and 0.02 for salivary calprotectin. Correlations with histologic disease activity were 0.80 for fecal calprotectin, 0.55 for plasma calprotectin, 0.15 for serum calprotectin, and -0.03 for salivary calprotectin. Fecal calprotectin had the strongest correlations with endoscopic and histologic disease outcomes, but fecal calprotectin levels were lower among those with ileal disease. For blood-based calprotectin, plasma calprotectin had a higher correlation with histology than serum, and plasma calprotectin levels were higher among those with ileal disease.
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