ArticleMolecular neurobiology2025
Inhibition of the HIF-1α Signaling Pathway Promotes Oligodendrocyte Maturation in the In Vitro Model of Perinatal Asphyxia.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Preterm or complicated labor is often accompanied by the asphyxia of the newborn. Temporal limitation of oxygen and nutrient supply can be especially harmful to the developing brain and lead to hypoxic-ischemic encephalopathy. This injury is mainly caused by the reduction in white matter volume and may be triggered by delayed maturation of oligodendrocytes and affected myelination. One of the key factors involved in the pathophysiology of neural tissue after asphyxia is the activation of hypoxia-inducible factor 1α (HIF-1α) signaling. The objective of the study was to verify whether this factor is involved in affected oligodendrocyte differentiation in this injury and whether its modulation can be considered as a treatment of hypoxic-ischemic encephalopathy. In the study, we mimicked the hypoxic-ischemic injury to in vitro cultured oligodendrocyte progenitor cells obtained from rat pups. Cells were deprived of culture medium and exposed to 50 min of oxygen deficit. After the insult, an enhanced activation (CoCl
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