Evidence map›Paper›PMID 40728748›Full record

ArticleMikrochimica acta2025

Precision photodamage of RNA and mitochondria for cancer therapy with upconversion nanoparticles.

Shuwen Cheng, Menghang Chen, Yihan Wu, Jinliang Liu, Xiaoqin Zhong, Yong Zhang, Qingqing Dou

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuwen ChengSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Menghang ChenSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Yihan WuSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Jinliang LiuSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China.
Xiaoqin ZhongDepartment of Biomedical Engineering, City University of Hong Kong, Hong Kong, 999077, SAR, China. xiaoqin_zhong@shu.edu.cn.
Yong ZhangPeriodicals Agency of Shanghai University, Shanghai University, Shanghai, 200444, China. yozhang@cityu.edu.hk.
Qingqing DouSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China. douq@shu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) is an emerging approach for cancer treatment that circumvents the discomfort associated with surgical interventions; however, its therapeutic effectiveness remains constrained. In this study, an innovative nanoplatform is introduced that is designed to enhance the efficacy of PDT by specifically targeting RNA and mitochondria, along with providing real-time in vivo imaging capabilities. The nanoplatform is constructed from a multifunctional nanocomposite, UCNP@PEI-RB-furan (referred to as UPRf), integrates several critical components: upconversion nanoparticles (UCNPs) to facilitate light penetration into deep tissue, Rose Bengal (RB) to generate reactive oxygen species (ROS) including singlet oxygen (

Indexed as

MitochondriaNanoparticlesPhotochemotherapyPhotosensitizing AgentsRNAAnimalsCell Line, TumorHumansMiceNeoplasmsPolyethyleneimineReactive Oxygen SpeciesRose BengalSinglet OxygenPhotosensitizing AgentsPolyethyleneimineReactive Oxygen SpeciesRNARose BengalSinglet OxygenMitochondria targetingPhotodynamic therapyRNA targetingUpconversion nanoparticles

Identifiers

PMID40728748

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.