Evidence map›Paper›PMID 40728723›Full record

ArticleInternational journal of legal medicine2025

Inversion time optimization in postmortem 1.5 tesla FLAIR brain imaging: a pilot study.

Christine Bruguier, V Magnin, J-F Knebel, S Grabherr, V Dunet, P Genet

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Article in International journal of legal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Christine BruguierDepartment of Medical Radiology, Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, Lausanne, 1011, Switzerland. christine.bruguier@chuv.ch.
V MagninDepartment of Medical Radiology, University Center of Legal Medicine of Lausanne- Geneva, Lausanne University Hospital and University of Lausanne, Vuillette 4, Lausanne 5, 1000, Switzerland.
J-F KnebelDepartment of Medical Radiology, Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, Lausanne, 1011, Switzerland.
S GrabherrDepartment of Medical Radiology, University Center of Legal Medicine of Lausanne- Geneva, Lausanne University Hospital and University of Lausanne, Vuillette 4, Lausanne 5, 1000, Switzerland.
V Dunet *Department of Medical Radiology, Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, Rue du Bugnon 46, Lausanne, 1011, Switzerland.
P Genet *Department of Medical Radiology, University Center of Legal Medicine of Lausanne- Geneva, Lausanne University Hospital and University of Lausanne, Vuillette 4, Lausanne 5, 1000, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPostmortem magnetic resonance imaging (PMMR) has gained importance during the last decade in forensic pathology. While many clinical radiology sequences are applicable for the evaluation of the brain, the 3D FLAIR sequence shows different contrast in postmortem cases compared to living patients. Two factors-the temperature and the interval between official declaration of the death and PMMR (DC-PMMR interval) are suspected to influence the optimal inversion time (TI) needed to achieve living patient-like image contrast. This study aimed to investigate if our empirical approach had the same results as previous study. MATERIALS AND

methods3D FLAIR sequences with varying TI values (from 1660 ms to 900 ms, every 110 ms) were acquired. Two radiologists independently assessed the images, selecting the TI that produced the most patient-like contrast. Rectal temperature and the DC-PMMR interval were recorded, and Pearson correlation tests were conducted to evaluate interrelations between TI, temperature, and DC-PMMR interval. Interobserver reliability was assessed using PABAK.

resultOverall, 23 cases were analyzed. Rectal temperature ranged from 5.7 °C to 29.0 °C, and the DC-PMMR interval from 13.05 to 768 h. A moderate interobserver reliability (PABAK = 0.56) was observed. Significant correlations were observed between TI and both temperature (r = 0.70, p = 0.0014) and DC-PMMR interval (r = - 0.68, p < 0.0003).

conclusionOur empirical approach trends the results of previous studies: Postmortem 3D FLAIR contrast is significantly affected by the temperature and the DC-PMMR interval, suggesting that TI should be adapted accordingly.

Indexed as

BrainMagnetic Resonance ImagingPostmortem ChangesAdultAgedAged, 80 and overAutopsyBody TemperatureFemaleForensic PathologyHumansImaging, Three-DimensionalMaleMiddle AgedPilot ProjectsReproducibility of Results3D FLAIR sequenceBrainPostmortem MRITime inversion

Identifiers

PMID40728723
PMCPMC12532620

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