SynthesisInflammopharmacology2025
Is ibuprofen associated with upper gastrointestinal bleeding? A systematic review and meta-analysis.
Synthesis in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious systematic reviews associated nonsteroidal anti-inflammatory drugs (NSAIDs) with upper gastrointestinal bleeding (UGIB) without comparing ibuprofen to paracetamol. We systematically reviewed and meta-analyzed studies comparing ibuprofen against paracetamol, placebo, non-users, or other NSAIDs on their association with UGIB.
methodsWe searched PubMed, CENTRAL, Web of Science, Scopus, ClinicalTrials.gov, and WHO ICTRP for randomized clinical trials (RCTs) and observational studies and assessed their risk of bias. We utilized random-effects models, calculated odds ratios (OR) or risk ratios (RR) with their 95% confidence intervals (CI), and evaluated the certainty of the evidence.
resultsWe identified seven RCTs and 10 observational studies recruiting 89,522 participants. Ibuprofen intake ranged mostly from up to 1,200 mg to 1,800 mg daily, and its median exposure window was 1.5 weeks. After removing a potentially influential case, ibuprofen compared to paracetamol was not associated with UGIB (OR: 0.96, 95% CI: 0.36 to 2.59, p = 0.9341, I
conclusionLow-dose and short-term ibuprofen administration may not be associated with UGIB compared to paracetamol or other non-selective NSAIDs. Future research should investigate dose-response relationships.
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