Evidence map›Paper›PMID 40728663›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025

OF-score for osteoporotic thoracolumbar fractures- which parameter is decisive for the therapy decision? - a prospective multicentric cohort study.

Bernhard Wilhelm Ullrich, Philipp Schenk, Michael A Scherer, Michael Müller, Georg Osterhoff, Gregor Schmeiser, Max J Scheyerer, Ulrich J Spiegl, Falko Schwarz, Alexander Franck and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Bernhard Wilhelm UllrichDepartment for Trauma and Reconstructive Surgery BG Klinikum Bergmannstrost gGmbH Halle, Halle, Germany. b.w.ullrich@me.com.
Philipp SchenkDepartment of Science, Research and Education, BG Klinikum Bergmannstrost Halle gGmbH, Halle, Germany.
Michael A SchererMedical Practice Clinic Orthopedics and Surgery Munich West, Munich, Germany.
Michael MüllerDepartment of Orthopedics and Traumatology, University of Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Georg OsterhoffDepartment of Orthopaedics, Trauma and Plastic Surgery, University Hospital Leipzig, Leipzig, Germany.
Gregor SchmeiserDepartment of Spine Surgery, Schoen-Clinic Hamburg Eilbek, Hamburg, Germany.
Max J ScheyererDepartment for Orthopedics und Traumatology University Hospital Düsseldorf, Düsseldorf, Germany.
Ulrich J SpieglClinic for Trauma, Orthopedic, Reconstructive and Handsurgery, Munich Clinic Harlaching, Munich, Germany.
Falko SchwarzDepartment of Neurosurgery, University Hospital Jena, Jena, Germany.
Alexander FranckDepartment of Orthopaedics and Trauma Surgery, Sana Kliniken Oberfranken, Klinikum Coburg, Coburg, Germany.
Volker ZimmermannDepartment of Orthopaedics and Trauma Surgery, Klinikum Traunstein, Traunstein, Germany.
Martin BäumleinDepartment of Orthopaedics and Traumatology, University Hospital Marburg, Marburg, Germany.
Sebastian KatscherSana Klinikum Borna, Department of Spine Surgery and Neurotraumatology, Borna, Germany.
Klaus SchnakeInterdisciplinary Center for Spine and Scoliosis Surgery, Malteser Waldkrankenhaus St. Marien, Erlangen, Erlangen, Germany.
Working Group Osteoporotic Fractures Spine Section Of The German Society Of Orthopedics And TraumaSpine Section of the German Society of Orthopedics and Trauma, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionVarious treatment strategies for osteoporotic vertebral compression fractures (OVCF) have been proposed, with the OF-score being a promising tool for therapeutic decision-making. The aim of this study is to determine the significance of the individual components of the OF-score for the therapy recommendation. Furthermore, score modifications will be sought that lead to improved agreement between the score recommendation and clinically successful therapy.

methodsData from the prospective multicenter study "Clinical evaluation of the OF-score for therapy planning and treatment recommendation for osteoporotic fractures of the thoracolumbar spine" (EOFTT) with 518 patients (128 male, 390 female), including 344 surgically and 174 conservatively treated, were used. Binary discriminant analysis and logistic regression models were applied to analyze the predictive power of OF-score variables for the treatment decision. ROC analysis determined the predictive value of VAS pain, with thresholds defined using the Youden index.

resultsA total of 508 patients were analyzed. Binary discriminant analysis showed an explanatory power of 79.7%, and logistic regression showed 80.4%. The most powerful variables were VAS pain (0.809), mobilization (-0.405), and OF classification (0.302). ROC analysis identified a VAS threshold of 5.5 for surgical treatment (AUC = 0.811, p < 0.001). A VAS threshold of ≥ 5 yielded the highest accuracy (71.5%), while thresholds ≥ 4 had the highest sensitivity (71.9%) and ≥ 6 the highest specificity (82.0%).

conclusionsA modified OF-score with a VAS pain threshold of ≥ 5 improves accuracy and balances specificity and sensitivity. Despite this adjustment, the OF-score's predictive power of 80% remains underutilized. Further research could enhance the clinical utility of the modified score and explore the potential of other variables.

Indexed as

Clinical Decision-MakingFractures, CompressionLumbar VertebraeOsteoporotic FracturesSpinal FracturesThoracic VertebraeAgedAged, 80 and overCohort StudiesFemaleHumansMaleMiddle AgedPain MeasurementProspective StudiesFactors for therapy decisionOF-classificationOF-scoreOsteoporotic thoracolumbar fractureTreatment decisionVertebral body compression fracture

Identifiers

PMID40728663

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