ReviewIntensive care medicine2025
Norepinephrine pharmacolexicology: a chronological review of dose reporting and the implications of salt formulations.
Review in Intensive care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Remimazolam in pediatric anesthesia: a systematic review for clinical decision-making.Frontiers in pediatrics · 2025Pooled it
- Preemptive noradrenaline infusion: a game-changer against post-induction hypotension in surgical sepsis: a randomized double blind trial.BMC anesthesiology · 2026Trial
- The effect of intravenous calcium administration on haemodynamics in perioperative cardiothoracic surgery and intensive care: A narrative review.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Review
- Clinical criteria for the definition of refractory septic shock: a joint Delphi consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM).Intensive care medicine · 2026Article
- Perioperative Vasopressor Management in Noncardiac Surgical Patients.Anesthesiology · 2026Article
- Early Methylene Blue for Mortality Reduction in High-Dose VasoPREssor-Dependent Septic Shock (EMPRESS): protocol for a multicenter randomized controlled trial.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- Inhomogeneity of noradrenaline levels in syringe pump systems and how to prevent it: an in vitro study.BMC anesthesiology · 2026Article
- Norepinephrine formulation itself does not constitute heterogeneity in shock trials.Critical care (London, England) · 2025Article
- Circulating biomarkers of vasoplegia: a systematic review.Annals of intensive care · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uncertainties in norepinephrine dose reporting due to variable labeling practices secondary to salt formulation considerations have resulted in significant clinical and research challenges, potentially leading to impaired comparability across studies. The objective of this review was to summarize the chronology of the available literature on the issue of norepinephrine salt formulations and dose reporting. A systematic search of PubMed/MEDLINE, EMBASE, and Google Scholar databases was conducted to identify pertinent studies addressing the variability in norepinephrine salt formulations and labeling practices, the evolution of pharmacological understanding, and recent developments in proposed guidelines. The included investigations were then synthesized in a narrative fashion and subsequently organized chronologically to trace the progression of findings over time, thus highlighting the implications of dosing variability, and provide insight into strategies that may be used to attain global harmonization in norepinephrine dose reporting. National efforts-such as the United States Salt Policy and the French implementation model-offer a structured pathway toward harmonization. Consistency in norepinephrine dose reporting globally is of upmost importance such that trials may be designed appropriately, evidence syntheses may be interpreted appropriately, and research findings may be appropriately used to inform clinical practice.
Indexed as
Identifiers
40728635What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.