Evidence map›Paper›PMID 40728602›Full record

ArticleBiogerontology2025

Influence of a diet with potential geroprotectors on blood biochemistry and aging-associated markers in domestic cats: a pilot study.

Vladimir A Protopopov, Alexey V Sekunov, Tatiana V Toropova, Irina G Bryndina, Dilyara N Burganova, Vyacheslav B Milaev, Mariya B Sharafislamova, Sergey V Pozdeev, Alexey A Moskalev

Abstract read
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In one paragraph

Article in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vladimir A ProtopopovDepartment of Pathophysiology and Immunology, Izhevsk State Medical Academy, Kommunarov Street, Izhevsk, 426000, Russia. vladimirvst@yandex.ru.ORCID 0000-0003-4058-8155
Alexey V Sekunov *Department of Pathophysiology and Immunology, Izhevsk State Medical Academy, Kommunarov Street, Izhevsk, 426000, Russia.ORCID 0000-0002-1592-2927
Tatiana V Toropova *Department of Internal Diseases and Surgery, Udmurt State Agrarian University, Lenina Street, Izhevsk, 426000, Russia.ORCID 0009-0001-0230-3190
Irina G Bryndina *Department of Pathophysiology and Immunology, Izhevsk State Medical Academy, Kommunarov Street, Izhevsk, 426000, Russia.ORCID 0000-0003-4099-4508
Dilyara N Burganova *Department of Pathophysiology and Immunology, Izhevsk State Medical Academy, Kommunarov Street, Izhevsk, 426000, Russia.ORCID 0009-0003-9629-8955
Vyacheslav B Milaev *Department of Internal Diseases and Surgery, Udmurt State Agrarian University, Lenina Street, Izhevsk, 426000, Russia.
Mariya B Sharafislamova *Department of Internal Diseases and Surgery, Udmurt State Agrarian University, Lenina Street, Izhevsk, 426000, Russia.ORCID 0009-0008-2256-4364
Sergey V Pozdeev *Depatment of Research and Development, Limited Liability Company "Spring", Vasilkovaya Street, Izhevsk, 426000, Russia.ORCID 0009-0008-1265-7997
Alexey A Moskalev *Longevity Institute of Russian Research Surgery Center, Abrikosovsky Lane 2, Moscow, Russia. amoskalev@med.ru.ORCID 0000-0002-3248-1633

Funding

Innovation Assistance Fund grant 4959GS1/85498Petrovsky National Research Center of Surgery FURG-2025-0059
6 · The paper itself

Abstract

This pilot study aimed to evaluate the impact of a diet supplemented with potential geroprotectors on metabolic and aging-associated markers in domestic cats. A total of 53 adult domestic cats were randomly assigned into two groups: a control diet (CD) and a geroprotective diet (GD) containing five plant-based extracts (silymarin, green tea, grape seed, curcumin, and grapefruit seed). Animals were fed the respective diets for three months. Body weight and body condition score were recorded before and after the feeding period. Blood samples were analyzed for standard biochemical parameters. Peripheral blood mononuclear cells were isolated to assess the expression of markers associated with inflammation (NF-κB, IL-1β), senescence (p16), and metabolic regulation (SIRT1, Klotho, RAGE) by Western blot. Both diets supported adequate body weight and condition. The GD group demonstrated a significant reduction in serum creatinine and a marked decrease in inflammatory and senescence markers (lower RAGE, p16, phospho-NF-κB) compared to baseline. SIRT1 levels were significantly upregulated only in the GD group, suggesting a possible protective mechanism against age-related changes. These data reveal a mechanistic link between dietary geroprotector supplementation and the modulation of key molecular hallmarks of aging in felines, highlighting conserved pathways of aging across mammalian species and establishing a foundation for translational interventions targeting age-associated decline in companion animals. Further long-term and larger-scale studies are required to confirm and extend these observations.

Indexed as

AgingDietDietary SupplementsPlant ExtractsAnimalsBiomarkersCatsFemaleMalePilot ProjectsSirtuin 1BiomarkersPlant ExtractsSirtuin 1AgingCatsDietGeroprotectorInflammationMetabolism

Identifiers

PMID40728602

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.