ArticleDigestive diseases and sciences2025
Clinical Characteristics and Outcomes of Hypertriglyceridemic Acute Pancreatitis Concomitant with Diabetic Ketoacidosis.
Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Incidence and Predictors of Acute Pancreatitis in Patients With Diabetic Ketoacidosis (DKA) and Hyperosmolar Hyperglycemic State (HHS): A Multicenter Retrospective Study.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2026Article
- Phenyllactic Acid Restores Intestinal Epithelial Barrier to Alleviate Hypertriglyceridemic Acute Pancreatitis via a PPARγ-Dependent Mechanism.Antioxidants (Basel, Switzerland) · 2026Article
- Beyond triglyceride clearance: rethinking hypertriglyceridemia-associated acute pancreatitis in the apoC-III era.Gastroenterology report · 2026Review
- Multidisciplinary Management and Anesthesia Considerations for Diabetic Ketoacidosis With Hypertriglyceridemic Acute Pancreatitis in Pregnancy: A Case Report.The American journal of case reports · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesHypertriglyceridemic acute pancreatitis (HTG-AP) is the common cause of acute pancreatitis (AP) after gallstones and alcohol abuse, accounting for up to 10% of the cases of acute pancreatitis. Diabetic ketoacidosis (DKA) may potentially complicate the diagnosis, treatment, and clinical outcomes of HTG-AP. This study aimed to directly compare the clinical characteristics and outcomes of HTG-AP in patients with and without DKA.
methodsA retrospective analysis was conducted on 289 patients diagnosed with HTG-AP, among whom 23 were also diagnosed with DKA. Epidemiologic characteristics, initial laboratory values, and clinical outcomes were compared between the DKA and non-DKA groups.
resultsThe DKA group exhibited a higher incidence of severe acute pancreatitis (SAP) following nearest-neighbor 1:2 propensity score matching. HTG-AP patients with DKA experienced longer ICU durations and needed more interventions for intraabdominal bleeding. Additionally, the DKA group presented with higher BMI, a greater prevalence of medical history in circulatory disease, diabetes mellitus and hyperlipidemia. In addition, the levels of glucose, procalcitonin (PCT), and C-reactive protein (CRP) were more elevated in patients with DKA.
conclusionsConcomitant with DKA in HTG-AP patients is linked to increased persistent organ failure, prolonged ICU duration, and increasing need for interventions in the bleeding patients. However, HTG-AP patients with DKA have no effect on the length of stay, in-hospital mortality, incidence of infected necrotizing pancreatitis and the necessity for necrosectomy.
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