Evidence map›Paper›PMID 40728573›Full record

ReviewGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025

Early-stage diabetic retinopathy: gut-metabolic triggers, immune-neurodegeneration, and interventions.

Jing Niu, Yi Liu, Hui Peng, Jun Chen, Lei Chen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Microglia response and function in a chronic model of photoreceptor damage.Frontiers in cell and developmental biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jing Niu *School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Yi Liu *School of Chinese Medicine, Southern Medical University, Guangzhou, 510515, China. liuyi099@163.com.
Hui PengSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Jun ChenSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Lei ChenSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China. chenlei0080@163.com.ORCID http://orcid.org/0009-0007-4525-197X

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515011060Basic and Applied Basic Research Foundation of Guangdong Province 2024A1515011704Basic and Applied Basic Research Foundation of Guangdong Province Guangdong Natural Science Fund
6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a major cause of blindness in the working-age population globally, with its prevalence steadily increasing. This study comprehensively reviews the pathogenesis and progression of DR through a literature review and reveals that chronic hyperglycemia, inflammation, oxidative stress, and dysregulation of gut microbiota and their metabolites in diabetes mellitus (DM) play significant roles in triggering ocular immune activation and early retinal neurodegeneration related to DR. The study details the processes of ocular immune activation and early retinal neurodegeneration influenced by these causative factors and explores potential future therapeutic strategies. Ultimately, this work aims to promote effective early intervention strategies for preventing DR onset and progression.

Indexed as

Diabetic RetinopathyGastrointestinal MicrobiomeRetinaDisease ProgressionHumansOxidative StressDiabetic retinopathyGut-retina axisMicrogliaNeurodegeneration

Identifiers

PMID40728573

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.