Evidence map›Paper›PMID 40728521›Full record

ArticleThe Journal of cell biology2025

New insights into lipid droplet breakdown in alcohol-associated hepatic steatosis.

Chen Zhang, Wen-Xing Ding

Abstract read
In one paragraph

Article in The Journal of cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chen ZhangDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0001-7609-980X
Wen-Xing DingDepartment of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0002-3167-5073

Funding

Mechanisms regulating autophagy in alcohol-induced liver injuryR37AA020518 · NIAAA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Wen-Xing Ding · 2019 to 2026
$3.2M
Mechanisms of mitochondrial dynamics, quality control and mtDNA-mediated inflammation in alcohol-associated liver diseaseR01AA031230 · NIAAA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Wen-Xing Ding · 2024 to 2026
$1.2M
Novel mechanisms of regulating endoplasmic reticulum homeostasis in alcoholic pancreatitisR21AA030617 · NIAAA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DING, WEN-XING · 2023 to 2023
$407k
NIAAA NIH HHS R01 AA031230NIAAA NIH HHS R21 AA030617NIAAA NIH HHS R37 AA020518NIH HHS R01AA031230NIH HHS R21 AA030617NIH HHS R37 AA020518
6 · The paper itself

Abstract

The mechanisms by which alcohol increases lipid droplet accumulation are still unclear. In this issue, Sen et al. (https://doi.org/10.1083/jcb.202408205) identify a new pathway through which chronic alcohol exposure promotes hepatic steatosis via a UBXD8-p97/VCP-HSD17β13 axis, which regulates lipid droplet homeostasis.

Indexed as

EthanolFatty Liver, AlcoholicLipid DropletsAnimalsHumansLipid MetabolismEthanol

Identifiers

PMID40728521
PMCPMC12306896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.