Evidence map›Paper›PMID 40728309›Full record

ArticleSleep2025

Rest-activity rhythms are stronger in Mexican American compared to non-Hispanic White and Black participants: a cross-sectional study.

Clémence Cavaillès, Katie L Stone, Yue Leng, Kristine Yaffe

Abstract read
In one paragraph

Article in Sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Clémence CavaillèsDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, United States.ORCID 0000-0002-8443-2307
Katie L StoneResearch Institute, California Pacific Medical Center, San Francisco, CA, United States.
Yue LengDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, United States.
Kristine YaffeDepartment of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, United States.

Funding

The Health & Aging Brain Study - Health Disparities (HABS-HD)U19AG078109 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Sid E O'Bryant · 2022 to 2026
$181.1M
Sleep Quality and Mechanistic Links to Alzheimer Disease and Related Disorders among older Mexican Americans and Non-Hispanic WhitesR01AG066137 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI O'BRYANT, SID E, YAFFE, KRISTINE · 2019 to 2023
$4.3M
Population Based Research for Alzheimer's Innovation (POP BRAIN)R35AG071916 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YAFFE, KRISTINE · 2021 to 2024
$3.8M
Lifecourse sleep, cognitive decline and risk of Alzheimer's disease: a pooled cohort study.R01AG083836 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Yue Leng · 2024 to 2026
$2.1M
NIA NIH HHS R01 AG066137NIA NIH HHS R01 AG083836NIA NIH HHS R35 AG071916NIA NIH HHS U19 AG078109
6 · The paper itself

Abstract

STUDY

objectivesThis study aimed to investigate differences in rest-activity rhythms (RAR), key circadian rhythm markers, across race/ethnicity and sex in a diverse community-based cohort of older adults.

methodsWe examined RAR (amplitude [strength of activity], mesor [level of activity], acrophase [time of peak activity], and pseudo-F [robustness of activity]) derived from the extended cosinor model based on ≥4 24-hour periods of wrist actigraphy among 756 participants (≥50 years) in the Dormir Study. We conducted linear and multinomial logistic regression models adjusted for socioeconomic status, health conditions, and sleep-related factors.

resultsWe studied 218 (28.8%) Black, 221 (29.2%) Mexican American (MA), and 317 (42.0%) non-Hispanic White (NHW) participants, with a mean age of 66.3 ± 8.4 years, and 66.8% women. Compared to NHW adults, MA participants exhibited healthier RAR, with lower odds of being in the lowest tertile for amplitude and mesor, and higher odds of being in the later tertile for acrophase. Black participants had lower odds of being in the earlier tertile for acrophase. Overall, women had better RAR values than men, with lower odds of being in the lowest tertile for amplitude and mesor, and higher odds of being in the later tertile for acrophase. Among subgroups, MA women exhibited the strongest RAR, while NHW men displayed the weakest patterns.

conclusionsRAR vary by race/ethnicity and sex, with MA participants and women exhibiting stronger rhythms. Further research is needed to understand if these different RAR patterns translate to other health outcomes and the mechanism underlying these differences. Statement of Significance Poor rest-activity rhythms (RAR) are linked to adverse health outcomes. Despite known sociodemographic disparities in many health factors, differences in RAR among diverse populations remain understudied. We investigated RAR pattern differences across race/ethnicity and sex in a diverse community-based cohort of older adults. Mexican American participants and women exhibited stronger rhythms, with notably higher amplitude and mesor values than non-Hispanic White and Black participants and men, independently of socioeconomic, health, and sleep-related factors. Further research is needed to understand if these different RAR patterns translate to other health outcomes and the mechanism underlying these differences.

Indexed as

Black or African AmericanCircadian RhythmMexican AmericansRestWhiteActigraphyAgedCross-Sectional StudiesFemaleHumansMaleMiddle Agedactigraphydiversityrace disparitiesrest-activity rhythmsex disparities

Identifiers

PMID40728309
PMCPMC12696381

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.