Evidence map›Paper›PMID 40728249›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

A Hydro-Expansive and Degradable Biomaterial Enabling Shape Recovery of Film-Based Devices in Biofluids.

Ruoxing Wang, Jiajie Sui, Pengfei Chen, Zulmari Silva-Pedraza, Jack Bontekoe, Jooyong Kim, Patrick Li, Fengdan Pan, Eric G Schmuck, Satoru Osaki and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ruoxing WangDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0002-0733-1094
Jiajie SuiDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Pengfei ChenDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Zulmari Silva-PedrazaDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Jack BontekoeDivision of Vascular Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Jooyong KimDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Patrick LiDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Fengdan PanDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Eric G SchmuckDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Satoru OsakiDivision of Cardiothoracic Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Bo LiuDepartment of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53705, USA.
Xudong WangDepartment of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.ORCID 0000-0002-9762-6792

Funding

Nanogenerator-Driven Self-Sustainable Power Source for Intracardiac PacemakersR01HL157077 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI WANG, XUDONG · 2021 to 2024
$2.7M
American Heart Association 23POST1010813NHLBI NIH HHS R01 HL157077NHLBI NIH HHS R01HL157077
6 · The paper itself

Abstract

Hygroscopic actuation is an important material function, which enables a broad range of applications such as self-healing devices, soft robotics, and catheter implantation. With the current paradigm of implantable devices shifting toward soft and tissue-mimicking systems, this function however, is particularly weak in soft- and bio-materials due to the rapid loss of intermolecular interactions upon water incorporation. Here, a chitosan-based bio-composite is developed, which sustains the intermolecular repulsive force during water absorption through synergistic effects of hydrogen bonding, plasticization, and nano-confinement. When interact with body fluids, this material provides a stable and strong tensile force throughout its volume expansion process. Therefore, it serves as a functional coating that self-flattens a thin film-based device which holds a tubular shape needed for catheter delivery, and then degrades naturally. This capability is further demonstrated in vivo using a rolled triboelectric nanogenerator (TENG) for intracardiac implantation. The TENG device recovers its original shape after being placed inside the heart left ventricle and restores its regular energy harvesting function, evidencing the feasibility for minimally invasive implantation of flexible film-based devices.

Indexed as

Biocompatible MaterialsBody FluidsAnimalsChitosanWaterBiocompatible MaterialsChitosanWaterbiocompatible and biodegradablechitosan‐based compositeshydration modulusionic cross‐linkingshape recovery

Identifiers

PMID40728249
PMCPMC12406138

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.