Ensemble of Bayesian alphabets via constraint weight optimization strategy improves genomic prediction accuracy.

This study proposes a weight optimization-based ensemble framework aimed at improving genomic prediction accuracy. It incorporates 8 Bayesian models-BayesA, BayesB, BayesC, BayesBpi, BayesCpi, BayesR, BayesL, and BayesRR in the ensemble framework, where the weight assigned to each model was optimized using genetic algorithm method. The performance of the ensemble model, named EnBayes, was evaluated on 18 datasets from 4 crop species, showing improved prediction accuracy compared to individual Bayesian models. New objective functions were proposed to improve prediction accuracy in terms of both Pearson's correlation coefficient and mean square error. The accuracy of the ensemble model was found to be associated with the number of models considered in the framework, where a few more accurate models achieved similar accuracy as that of more number of less accurate models. Additionally, over-bias and under-bias models also influenced the biasness of the ensemble model's accuracy. The study also explored a meta-learning approach using Bayesian models as base learners and random forest, quantile regression forest, and ridge regression as meta-learners, with the EnBayes model outperforming this approach. While traditional genomic prediction models GBLUP and rrBLUP and machine learning models support vector machine, random forest, extreme gradient boosting, and light gradient boosting were included in the ensemble framework in addition to Bayesian models, the ensemble model achieved higher accuracy as compared to the individual Bayesian, BLUP, and machine learning models. We believe that EnBayes would contribute significantly to ongoing efforts on improving genomic prediction accuracy.